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玻璃体腔内注射贝伐单抗(阿瓦斯汀®)治疗放射性视网膜病变:病例报告

[Treatment of radiation retinopathy with intravitreal injection of bevacizumab (Avastin®): case report].

作者信息

Lavezzo Marcelo Mendes, Hokazono Kenzo, Takahashi Walter Yukihiko

机构信息

Clínica Oftalmológica, Faculdade de Medicina, Universidade de São Paulo - USP, São Paulo, SP, Brasil.

出版信息

Arq Bras Oftalmol. 2010 Jul-Aug;73(4):373-736. doi: 10.1590/s0004-27492010000400016.

Abstract

To report a case of radiation retinopathy treatment with intravitreal injection of bevacizumab (Avastin®) in a patient undergoing radiotherapy for lymphoma in the right orbit. Patient of 55 years-old male, diabetic, diagnosed with an orbital MALT lymphoma three years ago, treated with local radiotherapy (dose: 35Gy) two years ago, complaining of reduced visual acuity of the right eye for about four months. During the ophthalmologic evaluation, he had an exam suggestive of radiation retinopathy. Macular thickness at the optical coherence tomography was 480 µm. Patient was referred to intravitreal injection (0.05 ml) of bevacizumab (Avastin®) in the right eye, showing reduction of macular edema and mild improvement of visual acuity. In this case, the treatment of radiation retinopathy with intravitreal injection of bevacizumab (Avastin®) was relatively useful, with mild improvement of visual acuity due to the regression of macular edema.

摘要

报告1例右眼眶淋巴瘤放疗患者玻璃体内注射贝伐单抗(阿瓦斯汀®)治疗放射性视网膜病变的病例。患者为55岁男性,患有糖尿病,3年前被诊断为眼眶黏膜相关淋巴组织淋巴瘤,2年前接受局部放疗(剂量:35Gy),近4个月来右眼视力下降。眼科评估时,检查提示放射性视网膜病变。光学相干断层扫描显示黄斑厚度为480µm。该患者接受了右眼玻璃体内注射(0.05ml)贝伐单抗(阿瓦斯汀®)治疗,黄斑水肿减轻,视力有轻度改善。在该病例中,玻璃体内注射贝伐单抗(阿瓦斯汀®)治疗放射性视网膜病变相对有效,黄斑水肿消退使视力有轻度改善。

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