Lorenzi Filho Geraldo, Genta Pedro Rodrigues, Pedrosa Rodrigo Pinto, Drager Luciano Ferreira, Martinez Denis
Disciplina de Pneumologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
J Bras Pneumol. 2010 Jun;36 Suppl 2:38-42. doi: 10.1590/s1806-37132010001400011.
Obstructive sleep apnea syndrome (OSAS) is a common condition associated with various cardiovascular diseases, including systemic arterial hypertension, atrial fibrillation, and atherosclerosis. The association between OSAS and cardiovascular disease has been related to the overlapping of risk factors, including obesity, having a sedentary lifestyle, being male, and being older. However, there is mounting evidence that OSAS can also independently contribute to the development and progression of various cardiovascular diseases. The mechanisms by which OSAS can affect the cardiovascular system are multiple, including the activation of the sympathetic nervous system, systemic inflammation, insulin resistance, and oxidative stress. There is also evidence that the treatment of OSAS with CPAP can reduce arterial blood pressure, early signs of atherosclerosis, the risk of atrial fibrillation recurrence, and mortality (principally mortality due to stroke or acute myocardial infarction) in patients with severe OSAS.
阻塞性睡眠呼吸暂停综合征（OSAS）是一种常见病症，与多种心血管疾病相关，包括系统性动脉高血压、心房颤动和动脉粥样硬化。OSAS与心血管疾病之间的关联与多种风险因素重叠有关，这些因素包括肥胖、久坐不动的生活方式、男性以及高龄。然而，越来越多的证据表明，OSAS也可独立促成各种心血管疾病的发生和发展。OSAS影响心血管系统的机制是多方面的，包括交感神经系统激活、全身炎症、胰岛素抵抗和氧化应激。也有证据表明，对重度OSAS患者采用持续气道正压通气（CPAP）治疗OSAS可降低动脉血压、动脉粥样硬化的早期迹象、心房颤动复发风险以及死亡率（主要是中风或急性心肌梗死导致的死亡率）。
