Kohler M, Russi E W, Bloch K E
Klinik für Pneumologie, Universitätsspital Zürich, Zürich.
Praxis (Bern 1994). 2010 Jan 20;99(2):117-22. doi: 10.1024/1661-8157/a000014.
The obstructive sleep apnoea syndrome (OSAS) is a highly prevalent sleep related breathing disorder associated with hypopnoea/apnoea, arousals and increased daytime sleepiness. OSAS has been shown to have damaging acute effects on the cardiovascular system and thus has been postulated to represent an independent cardiovascular risk factor. A causal relationship between OSAS and cardiovascular disease has currently only been established for hypertension and heart failure. Evidence that OSAS indeed plays a key role in the pathogenesis of heart attacks and stroke and that therapy of OSAS reduces cardiovascular morbidity and mortality is currently limited. The results of multiple ongoing international multi-centre studies investigating the effects of OSAS therapy on cardiovascular event rate and mortality are thus anxiously awaited.
阻塞性睡眠呼吸暂停综合征（OSAS）是一种与呼吸浅慢/呼吸暂停、觉醒及日间嗜睡增加相关的高度流行的睡眠呼吸障碍。OSAS已被证明对心血管系统有急性损害作用，因此被推测为一种独立的心血管危险因素。目前仅确定OSAS与心血管疾病之间的因果关系存在于高血压和心力衰竭中。目前，关于OSAS确实在心脏病发作和中风的发病机制中起关键作用以及OSAS治疗可降低心血管发病率和死亡率的证据有限。因此，人们急切期待正在进行的多项国际多中心研究的结果，这些研究旨在探究OSAS治疗对心血管事件发生率和死亡率的影响。
