Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2011 Jan-Feb;3(1):86-99. doi: 10.1002/wnan.115.
Apoptosis plays an important role in the loss of cardiomyocytes in both ischemic injury and heart failure. Pioneering work with single photon emission computed tomography imaging of (99)Tc-annexin showed that cell death in the heart could be imaged in vivo. Over the last 5 years a significant amount of experience with annexin-labeled magnetic nanoparticles, principally AnxCLIO-Cy5.5, has also been gained. Here, we review the experience with AnxCLIO-Cy5.5 in the heart and compare this experience to that of earlier studies with (99)Tc-annexin. The imaging of apoptosis with AnxCLIO-Cy5.5 provides valuable insights not only into molecular imaging in the heart but, more broadly, into the use of nanoparticle technology for molecular imaging in general.
细胞凋亡在缺血性损伤和心力衰竭中心肌细胞的丧失中起着重要作用。使用单光子发射计算机断层扫描成像技术对（99）Tc-annexin 的开创性研究表明，心脏中的细胞死亡可以在体内进行成像。在过去的 5 年中，还获得了大量关于 annexin 标记的磁性纳米颗粒（主要是 AnxCLIO-Cy5.5）的经验。在这里，我们回顾了 AnxCLIO-Cy5.5 在心脏中的应用经验，并将其与早期使用（99）Tc-annexin 的研究进行了比较。用 AnxCLIO-Cy5.5 进行细胞凋亡成像不仅为心脏的分子成像提供了有价值的见解，而且更广泛地为纳米颗粒技术在一般分子成像中的应用提供了见解。
