Influence of co-dergocrine on platelet aggregation.

In the present investigation, we studied the influence of co-dergocrine mesylate (dihydroergotoxin mesylate) on platelet aggregation induced by adrenaline, adenosine diphosphate (ADP) and collagen in vitro. Platelet-rich plasma was incubated with increasing concentrations of co-dergocrine (1.5, 3.0, 6.0, 12.0, 24.0, and 48.0 micrograms/ml). The lowest concentration of co-dergocrine tested (1.5 micrograms/ml) inhibited adrenaline-induced aggregation by 97%. Higher concentrations of the compound caused similar degrees of inhibition. ADP-induced aggregation was only decreased significantly (20%, P less than 0.001) by the highest concentration of co-dergocrine, whereas collagen-induced aggregation was not affected. Our results demonstrate that co-dergocrine selectively inhibits platelet aggregation triggered by adrenaline in vitro.