Lin C Y, Lubin B, Smith S
Biochim Biophys Acta. 1976 Mar 25;428(1):45-55. doi: 10.1016/0304-4165(76)90107-0.
The aggregation of platelets induced by ADP, collagen, or epinephrine in human platelet-rich plasma is inhibited by long chain acyl-CoA thioesters. Palmityl-CoA exerts a concentration dependent inhibition of collagen-induced aggregation and of the primary and secondary waves of ADP-induced aggregation. Palmityl-CoA also inhibits the secondary wave of epinephrine-induced aggregation but has no effect on the primary wave. This inhibitory effect of palmityl-CoA can be reversed by addition of excess ADP and cannot be attributed to a detergent action.
长链脂酰辅酶A硫酯可抑制人富血小板血浆中由二磷酸腺苷（ADP）、胶原蛋白或肾上腺素诱导的血小板聚集。棕榈酰辅酶A对胶原蛋白诱导的聚集以及ADP诱导聚集的初级和次级波具有浓度依赖性抑制作用。棕榈酰辅酶A还可抑制肾上腺素诱导聚集的次级波，但对初级波无影响。添加过量ADP可逆转棕榈酰辅酶A的这种抑制作用，且这种抑制作用并非归因于去污剂作用。
