Udowenko Marina, Trojian Thomas
PGY2 Family Medicine, University of Connecticut Health Center, USA.
Conn Med. 2010 Sep;74(8):477-80.
Vitamin D deficiencyis increasingly being identified in children, adolescents, and adults. Primary production of the active form of vitamin D occurs via a photolytic reaction induced by ultraviolet radiation B. Vitamin D has important effects on bone and muscle as well as on the immune system. Isolation ofa vitamin D receptor on muscle cells has been accompanied by studies showing receptor polymorphisms and age-related functional changeswhich have an effect on muscle performance. Insufficient levels havebeen associated with increased risk of stress fractures, decreased muscle performance, and increased sick days. Although there is still debate about the appropriate levels of vitamin D, studies have suggested a minimal level of 32 ng/ml. Supplementation serves as an inexpensive option associated with reduction in both morbidity and financial costs.
维生素D缺乏在儿童、青少年和成人中越来越多地被发现。维生素D的活性形式主要通过紫外线B诱导的光解反应产生。维生素D对骨骼、肌肉以及免疫系统都有重要影响。肌肉细胞上维生素D受体的分离伴随着相关研究，这些研究表明受体多态性和与年龄相关的功能变化会影响肌肉性能。维生素D水平不足与应力性骨折风险增加、肌肉性能下降和病假天数增加有关。尽管对于维生素D的适当水平仍存在争议，但研究表明最低水平为32纳克/毫升。补充维生素D是一种廉价的选择，可降低发病率和经济成本。
