红细胞前期疟原虫：非环子孢子蛋白抗原
Pre-erythrocytic stage malaria parasites: non-circumsporozoite protein antigens.
作者信息
Hollingdale M R, Aikawa M, Chen G X, Meis J F, Sakhuja K, Sina B, Zhu J D
机构信息
Biomedical Research Institute, Rockville, MD 20852.
出版信息
Bull World Health Organ. 1990;68 Suppl(Suppl):178-80.
Abstract
A series of non-circumsporozoite proteins found in pre-erythrocytic parasites are being developed as putative vaccine candidates. It is anticipated that these will be useful in addition to, rather than instead of, the CS (circumsporozoite) vaccines. It is likely that a greater understanding of the basic biology of malaria parasite-host relationships will lead to development of improved malarial vaccines.
摘要
在红细胞前期寄生虫中发现的一系列非环子孢子蛋白正被开发为假定的疫苗候选物。预计这些疫苗除了与环子孢子蛋白（CS）疫苗一起发挥作用外，还将起到补充作用，而非取而代之。对疟原虫与宿主关系基本生物学的更深入了解可能会推动改进型疟疾疫苗的研发。
相似文献
1
Pre-erythrocytic stage malaria parasites: non-circumsporozoite protein antigens.红细胞前期疟原虫：非环子孢子蛋白抗原
Bull World Health Organ. 1990;68 Suppl(Suppl):178-80.
2
Pre-erythrocytic malaria vaccine: mechanisms of protective immunity and human vaccine trials.红细胞前期疟疾疫苗：保护性免疫机制与人体疫苗试验
Parassitologia. 1999 Sep;41(1-3):397-402.
3
Towards an RTS,S-based, multi-stage, multi-antigen vaccine against falciparum malaria: progress at the Walter Reed Army Institute of Research.迈向基于RTS,S的多阶段、多抗原恶性疟疫苗：沃尔特·里德陆军研究所的进展
Vaccine. 2005 Mar 18;23(17-18):2243-50. doi: 10.1016/j.vaccine.2005.01.142.
4
Plasmodium falciparum CS C-terminal fragment: preclinical evaluation and phase I clinical studies.恶性疟原虫环子孢子蛋白C端片段：临床前评估与I期临床研究
Parassitologia. 1999 Sep;41(1-3):421-4.
5
[Malaria vaccine research].[疟疾疫苗研究]
Mikrobiyol Bul. 1986 Jan;20(1):37-41.
6
The development of malaria vaccines: SPf66--what next?疟疾疫苗的发展：SPf66——下一步何去何从？
Schweiz Med Wochenschr. 1996 Jul 9;126(27-28):1210-5.
7
Construction and evaluation of a multistage combination vaccine against malaria.一种抗疟疾多阶段联合疫苗的构建与评估
Vaccine. 2007 Mar 1;25(11):2112-9. doi: 10.1016/j.vaccine.2006.11.015. Epub 2006 Nov 21.
8
9
Recent advances in malaria research: parasite biology, chemotherapy and host/parasite relationships.疟疾研究的最新进展：寄生虫生物学、化疗及宿主/寄生虫关系
Ann Ist Super Sanita. 1985;21(3):271-90.
10
Genetic polymorphism in Plasmodium falciparum vaccine candidate antigens.恶性疟原虫疫苗候选抗原中的基因多态性。
Indian J Pathol Microbiol. 2005 Oct;48(4):429-38.
引用本文的文献
1
Long-term multiepitopic cytotoxic-T-lymphocyte responses induced in chimpanzees by combinations of Plasmodium falciparum liver-stage peptides and lipopeptides.恶性疟原虫肝期肽与脂肽组合在黑猩猩中诱导产生的长期多表位细胞毒性T淋巴细胞反应。
Infect Immun. 2004 Aug;72(8):4376-84. doi: 10.1128/IAI.72.8.4376-4384.2004.
本文引用的文献
1
Circumsporozoite proteins of human malaria parasites Plasmodium falciparum and Plasmodium vivax.人类疟原虫恶性疟原虫和间日疟原虫的环子孢子蛋白。
J Exp Med. 1982 Jul 1;156(1):20-30. doi: 10.1084/jem.156.1.20.
2
Hybridoma produces protective antibodies directed against the sporozoite stage of malaria parasite.杂交瘤产生针对疟原虫子孢子阶段的保护性抗体。
Science. 1980 Jan 4;207(4426):71-3. doi: 10.1126/science.6985745.
3
Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid.利用肽合成技术探测病毒抗原的表位，分辨率可达单个氨基酸水平。
Proc Natl Acad Sci U S A. 1984 Jul;81(13):3998-4002. doi: 10.1073/pnas.81.13.3998.
4
Specificity of protection of man immunized against sporozoite-induced falciparum malaria.针对子孢子诱导的恶性疟原虫疟疾进行免疫的人所具有的保护特异性。
Am J Med Sci. 1973 Dec;266(6):398-403. doi: 10.1097/00000441-197312000-00001.
5
Plasmodium falciparum gene encoding a protein similar to the 78-kDa rat glucose-regulated stress protein.恶性疟原虫基因，其编码一种与78 kDa大鼠葡萄糖调节应激蛋白相似的蛋白质。
Proc Natl Acad Sci U S A. 1988 Sep;85(17):6277-81. doi: 10.1073/pnas.85.17.6277.
6
Synthetic peptides from the circumsporozoite proteins of Plasmodium falciparum and Plasmodium knowlesi recognize the human hepatoma cell line HepG2-A16 in vitro.来自恶性疟原虫和诺氏疟原虫环子孢子蛋白的合成肽在体外可识别人类肝癌细胞系HepG2-A16。
J Exp Med. 1986 Dec 1;164(6):1915-22. doi: 10.1084/jem.164.6.1915.
7
Mature liver stages of cloned Plasmodium falciparum share epitopes with proteins from sporozoites and asexual blood stages.
Parasite Immunol. 1988 May;10(3):339-51. doi: 10.1111/j.1365-3024.1988.tb00225.x.
8
Non-CS pre-erythrocytic protective antigens.非环孢子素前红细胞保护性抗原。
Immunol Lett. 1990 Aug;25(1-3):71-6. doi: 10.1016/0165-2478(90)90094-7.
Zotero 插件