杂交瘤产生针对疟原虫子孢子阶段的保护性抗体。
Hybridoma produces protective antibodies directed against the sporozoite stage of malaria parasite.
作者信息
Yoshida N, Nussenzweig R S, Potocnjak P, Nussenzweig V, Aikawa M
出版信息
Science. 1980 Jan 4;207(4426):71-3. doi: 10.1126/science.6985745.
PMID:6985745
Abstract
Hybrid cells secreting antibodies against sporozoites of Plasmodium berghei were obtained by fusion of plasmacytoma cells with immune murine spleen cells. The monoclonal antibodies bound to a protein with an apparent molecular weight of 44,000 (Pb44), which envelopes the surface membrane of sporozoites. Incubation of sporozoites in vitro with antibodies to Pb44 abolished their infectivity.
摘要
通过将浆细胞瘤细胞与免疫小鼠脾细胞融合，获得了分泌抗伯氏疟原虫子孢子抗体的杂交细胞。这些单克隆抗体与一种表观分子量为44,000的蛋白质（Pb44）结合，该蛋白质包裹着子孢子的表面膜。在体外将子孢子与抗Pb44抗体一起孵育可消除其感染性。
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