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经辐照的疟原虫子孢子诱导的对恶性疟和间日疟的免疫力:马里兰大学1971 - 1975年研究综述

Immunity to falciparum and vivax malaria induced by irradiated sporozoites: a review of the University of Maryland studies, 1971-75.

作者信息

Clyde D F

机构信息

Department of Medicine, University of Maryland School of Medicine, Baltimore.

出版信息

Bull World Health Organ. 1990;68 Suppl(Suppl):9-12.

Abstract

The immunogenicity in adult male volunteers of sporozoites of Plasmodium falciparum and P. vivax was evaluated at the University of Maryland from 1971 to 1975. Inoculation of large numbers of sporozoites by mosquitos that had been X-irradiated proved safe and well tolerated, and the sporozoites were rendered noninfective. Three volunteers were protectively immunized by this method, one against P. falciparum, one against P. vivax, and one against both species. Protection was species- and stage-specific, but effective against all strains tested within a species, and was reflected by a rise in titre of antibody to the circumsporozoite protein.

摘要

1971年至1975年期间,马里兰大学评估了恶性疟原虫和间日疟原虫子孢子在成年男性志愿者中的免疫原性。通过经X射线照射的蚊子接种大量子孢子被证明是安全且耐受性良好的,并且子孢子被灭活。三名志愿者通过这种方法获得了保护性免疫,一名针对恶性疟原虫,一名针对间日疟原虫,一名针对这两种疟原虫。保护作用具有种属和阶段特异性,但对一个物种内测试的所有菌株均有效,并且通过环子孢子蛋白抗体滴度的升高得以体现。

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