尿酸：帕金森病风险、诊断和预后的新型生物标志物。
Urate: a novel biomarker of Parkinson's disease risk, diagnosis and prognosis.
机构信息
Massachusetts General Hospital, 114 16th Street, Boston, MA 02129, USA.
出版信息
Biomark Med. 2010 Oct;4(5):701-12. doi: 10.2217/bmm.10.94.
Abstract
A growing number of studies have correlated higher urate levels with a lower risk of developing Parkinson's disease (PD) and with a favorable rate of disease progression, indicating that urate could be an important biomarker of the pathophysiology underlying PD. Dietary and genetic determinants of urate have also been linked to a reduced risk or delayed onset of PD. Based on the known antioxidant and metal complexing properties of urate, together with evidence for oxidative stress as a contributor to neurodegeneration in PD, urate may serve as an endogenous neuroprotectant that helps reduce the risk and rate of the disease. In this article we review the convergent biological, epidemiological and clinical data that identify urate as a promising biomarker of the risk, diagnosis and prognosis of PD.
摘要
越来越多的研究表明，尿酸水平与帕金森病（PD）的发病风险降低和疾病进展有利相关，这表明尿酸可能是 PD 潜在病理生理学的重要生物标志物。尿酸的饮食和遗传决定因素也与 PD 的风险降低或发病延迟有关。基于尿酸已知的抗氧化和金属络合特性，以及氧化应激是 PD 神经退行性变的一个促成因素的证据，尿酸可能作为一种内源性神经保护剂，有助于降低 PD 的发病风险和速度。在本文中，我们回顾了将尿酸确定为 PD 的风险、诊断和预后有希望的生物标志物的收敛性生物学、流行病学和临床数据。
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