Song Yanbo, March John
Department of Biological and Environmental Engineering, Cornell University, Ithaca, NY, 14853, USA.
Johnson and Johnson, China.
Biotechnol Notes. 2022 May 25;3:32-37. doi: 10.1016/j.biotno.2022.05.001. eCollection 2022.
There is a global increase in cases of hyperuricemia over the last 10 years. A critical component of serum uric acid control is the transport of uric acid to the intestinal lumen, which accounts for 30% of the uric acid eliminated from the serum. This mini review looks at two important aspects of elevated uric acid: the dynamics of intestinal uric acid transport and hyperuricemia co-morbidities. Elevated serum uric acid can lead to gout and it can also impact other diseases such as diabetes, cardiovascular diseases and nervous system diseases. The level of uric acid in the intestine could be related to the potential for uric acid to impact other morbidities. We review the evidence for this and what it would mean for persons with elevated serum uric acid.
在过去10年中，全球高尿酸血症病例呈上升趋势。血清尿酸控制的一个关键因素是尿酸向肠腔的转运，这占从血清中清除的尿酸的30%。本综述探讨了高尿酸的两个重要方面：肠道尿酸转运的动力学和高尿酸血症的合并症。血清尿酸升高可导致痛风，还会影响其他疾病，如糖尿病、心血管疾病和神经系统疾病。肠道中的尿酸水平可能与尿酸影响其他疾病的可能性有关。我们综述了相关证据以及这对血清尿酸升高的人意味着什么。
