眼作为肉样瘤病早期临床表现的常见部位。

The eye as a common site for the early clinical manifestation of sarcoidosis.

机构信息

Department of Ophthalmology, Bochum, Germany.

出版信息

Ophthalmic Res. 2011;46(1):9-12. doi: 10.1159/000321947. Epub 2010 Nov 23.

DOI:10.1159/000321947

PMID:21099232

Abstract

AIMS

Our purpose was to detect the rate of initial manifestation of sarcoidosis in the eye.

MATERIAL AND METHODS

We conducted a retrospective chart review in a sarcoidosis clinic in Germany. Ophthalmological data were obtained by using a standardized protocol, including the medical history, any comorbidity, onset and type of ocular manifestation that was evaluated by slit lamp, tonometry and fundoscopy.

RESULTS

In the cohort of 1,800 patients (mean age 38.1 ± 11.8 years), diagnosis of sarcoidosis was established most commonly by bilateral hilar lymphadenopathy (96.2%), histopathology (46.9%) or other organ manifestations. The initial clinical presentation of sarcoidosis (mean age 34.1 ± 10.8 years) had often been eye manifestation (21.2%). Within this group, anterior uveitis was most common (76.4%), followed by intermediate (17.3%) and posterior uveitis (4.7%).

CONCLUSIONS

The eye is commonly the first site for manifestation of sarcoidosis. Ophthalmologists have a critical role in establishing the diagnosis of sarcoidosis.

摘要

目的

本研究旨在检测眼部结节病的首发表现率。

材料与方法

我们在德国的一家结节病诊所进行了一项回顾性图表审查。通过使用标准化方案获取眼科数据，包括病史、任何合并症、眼部表现的发病和类型，这些表现通过裂隙灯、眼压和眼底镜进行评估。

结果

在 1800 例患者（平均年龄 38.1±11.8 岁）的队列中，结节病的诊断最常通过双侧肺门淋巴结肿大（96.2%）、组织病理学（46.9%）或其他器官表现来确定。结节病的首发临床表现（平均年龄 34.1±10.8 岁）常为眼部表现（21.2%）。在该组中，前葡萄膜炎最常见（76.4%），其次是中间葡萄膜炎（17.3%）和后葡萄膜炎（4.7%）。