Department of Obstetrics and Gynecology, University of Benin Teaching Hospital, Benin City, Edo State, Nigeria.
Int J Gynaecol Obstet. 2011 Jan;112(1):30-3. doi: 10.1016/j.ijgo.2010.07.027. Epub 2010 Oct 13.
To assess the effect of intermittent preventive treatment with sulfadoxine and pyrimethamine (IPT-SP) on placental parasitemia and maternal and perinatal outcome.
We compared placental malaria parasitemia during pregnancy and pregnancy outcome in 2 groups of women receiving antenatal care at University of Benin Teaching Hospital. One group was prophylactically treated with IPT-SP and the other was not treated.
The parasitemia rates for peripheral, placental, and cord blood were 11.9%, 11.4%, and 2.7% in the IPT-SP group (n=370) and 19.1%, 22.6%, and 6.2% in the control group (n=371) (P=0.006, P=0.002, and P=0.02, respectively). The treatment reduced the odds of placental parasitemia by 37% (OR 0.63; 95% CI, 0.48-0.81). Peripheral (P=0.002) and placental (P=0.001) parasitemia were significantly reduced in the subgroup of women who took 2 or 3 doses of SP. Fewer women (16.2%) in the IPT-SP group than the control group (23.7%) had symptomatic malaria. Anemia at delivery was significantly lower in the IPT-SP group (10.8 vs 1.6%). The risks of abortion, preterm delivery, and low birth weight were also significantly lower in the IPT-SP group.
IPT-SP is effective in preventing placental parasitemia, and reduces rates of malaria, maternal anemia, abortion, preterm delivery and low birth weight among pregnant women.
评估磺胺多辛-乙胺嘧啶间歇性预防治疗（IPT-SP）对胎盘疟原虫感染和母婴围生结局的影响。
我们比较了在贝宁大学教学医院接受产前保健的两组妇女的妊娠期间胎盘疟疾寄生虫血症和妊娠结局。一组预防性接受 IPT-SP 治疗，另一组未接受治疗。
IPT-SP 组（n=370）外周血、胎盘血和脐血的寄生虫血症率分别为 11.9%、11.4%和 2.7%，对照组（n=371）分别为 19.1%、22.6%和 6.2%（P=0.006，P=0.002 和 P=0.02）。治疗使胎盘寄生虫血症的几率降低了 37%（OR 0.63；95%CI，0.48-0.81）。接受 2 或 3 剂 SP 的亚组中，外周血（P=0.002）和胎盘血（P=0.001）寄生虫血症显著减少。IPT-SP 组（16.2%）比对照组（23.7%）出现症状性疟疾的妇女更少。IPT-SP 组分娩时贫血的发生率显著降低（10.8%比 1.6%）。IPT-SP 组流产、早产和低出生体重的风险也显著降低。
IPT-SP 可有效预防胎盘寄生虫血症，并降低孕妇疟疾、贫血、流产、早产和低出生体重的发生率。
