Ouédraogo Smaïla, Accrombessi Manfred, Diallo Ismaël, Codo Roussine, Ouattara Adama, Ouédraogo Laurent, Massougbodji Achille, Cot Michel
Unité de Formation et de Recherche en Science de la Santé, Université Joseph Ki-Zerbo, Ouagdougou, Burkina Faso.
Centre Hospitalier Universitaire Yalgadogo, Ouédraogo, Burkina Faso.
Pan Afr Med J. 2019 Sep 16;34:30. doi: 10.11604/pamj.2019.34.30.20013. eCollection 2019.
Placental malaria (PM) is an important predictor of infant morbidity and mortality in sub-Saharan Africa. Although placental histology is the gold standard test to diagnose PM, the placenta impression smears remains widely used in epidemiological studies. This study is set to evaluate the performance of placental impression smears to detect PM in pregnant women in southern Benin.
A cross-sectional analysis was performed on data collected in the framework a multicenter randomized clinical trial (Malaria in Pregnancy Preventive and Alternative Drugs). Samples from 491 pregnant women were examined in the district of Allada, Southern Benin. infections have been assessed in placental blood and placental biopsy.
Placental malaria detected by placenta impression smears and histology were prevalent in 11.4% and 10.8%, respectively. Sensitivity and specificity of placental impression smears were 90.6% and 98.4%. Among 55 pregnant women tested positive by placenta impression smears, 48 were positive by the histology, while 7 were negative (positive predictive value: 87.3%). Four hundred and twenty four (424) of the 429 tested negative by the placenta impression smears, were also negative according to histology whereas the rest (5 of 429) of the women were positive (negative predictive value: 98.8%).
Placenta impression smear is an accurate and easy method for the diagnosis of placental malaria.
胎盘疟疾（PM）是撒哈拉以南非洲地区婴儿发病和死亡的重要预测指标。尽管胎盘组织学是诊断PM的金标准检测方法，但胎盘印片在流行病学研究中仍被广泛使用。本研究旨在评估胎盘印片在贝宁南部孕妇中检测PM的性能。
对在多中心随机临床试验（孕期疟疾预防与替代药物）框架内收集的数据进行横断面分析。在贝宁南部的阿拉达地区对491名孕妇的样本进行了检查。已对胎盘血和胎盘活检中的感染情况进行了评估。
通过胎盘印片和组织学检测到的胎盘疟疾患病率分别为11.4%和10.8%。胎盘印片的敏感性和特异性分别为90.6%和98.4%。在通过胎盘印片检测呈阳性的55名孕妇中，48名经组织学检测呈阳性，7名呈阴性（阳性预测值：87.3%）。在429名经胎盘印片检测呈阴性的孕妇中，424名经组织学检测也呈阴性，其余5名（429名中的）孕妇呈阳性（阴性预测值：98.8%）。
胎盘印片是诊断胎盘疟疾的一种准确且简便的方法。
