Laboratory of Animal Infectious Disease and Microarray, Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China.
Res Vet Sci. 2011 Dec;91(3):382-3. doi: 10.1016/j.rvsc.2010.09.007. Epub 2010 Oct 13.
This study aimed to assess the ability of a Salmonella typhimurium-mediated Avain Reovirus DNA vaccine in eliciting antibody production. Six-day-old SPF chickens were orally immunized with SL7207 (pVAX-σC) twice at 2-week interval, detectable antibody was generated 2 weeks after immunization and was significantly higher than the control groups (P<0.01) and ten chickens (66.7%) were considered safe in the subsequent challenge. These results show that SL7207 (pVAX-σC) can induce protective antibody in chickens and the newly-constructed vaccine is also effective in protection chickens against ARV infection.
本研究旨在评估鼠伤寒沙门氏菌介导的禽呼肠孤病毒 DNA 疫苗诱导产生抗体的能力。6 日龄 SPF 鸡用 SL7207（pVAX-σC）经口免疫两次，间隔 2 周，免疫后 2 周即可检测到抗体，且显著高于对照组（P<0.01），随后的攻毒试验中，10 只鸡（66.7%）被认为是安全的。这些结果表明，SL7207（pVAX-σC）可诱导鸡产生保护性抗体，且新构建的疫苗也可有效保护鸡免受 ARV 感染。
