选择性抑制 HDAC6 的酶和细胞抑制剂。
Inhibitors selective for HDAC6 in enzymes and cells.
机构信息
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
出版信息
Bioorg Med Chem Lett. 2010 Dec 1;20(23):7067-70. doi: 10.1016/j.bmcl.2010.09.100. Epub 2010 Oct 12.
PMID:20947351
Abstract
Histone deacetylase inhibitors with anticancer or anti-inflammatory activity bind to Class I or Class I and II HDAC enzymes. Here we compare selectivity of inhibitors of a Class II HDAC enzyme (HDAC6) and find one that retains high selectivity in macrophages.
摘要
具有抗癌或抗炎活性的组蛋白去乙酰化酶抑制剂与 I 类或 I 类和 II 类 HDAC 酶结合。在这里，我们比较了 II 类 HDAC 酶（HDAC6）抑制剂的选择性，并发现一种在巨噬细胞中保持高选择性的抑制剂。
Zotero 插件