University of Louisville School of Medicine, 323 E. Chestnut St., Louisville, KY 40292, USA.
Spine J. 2011 Jun;11(6):534-7. doi: 10.1016/j.spinee.2010.09.001. Epub 2010 Oct 14.
Considerable debate exists regarding the incidence of persistent pain from the iliac crest bone graft (ICBG) harvest site. Different study designs have led to a variety of reported rates.
The purpose of this study was to determine the incidence and severity of bone graft site pain after iliac crest harvest.
Cross-sectional.
One hundred and twelve patients, who had a posterior lumbar fusion, seen at a tertiary spine center for a routine postoperative visit.
Numeric rating scales (0-10) for pain over lower back, right, and left posterior iliac crests.
An independent investigator, not directly involved in the care of the patient and unaware of the type of bone graft used in the fusion, examined the patient for tenderness over the surgical site as well as the left and right posterior iliac crest. After the examination, data on the source of grafting material, complications during harvest, and backfilling of the graft site defect were collected from the medical records. The patients were then classified as to whether ICBG was harvested or not. Chi-square test was used to determine any difference in the proportion of iliac crest pain between the bone graft group and no bone graft group. Correlations between body mass index (BMI), time since surgery, and the incidence and severity of bone graft site pain were also determined.
There were 72 women and 40 men with a mean age of 56.6 years (range, 16-84). Mean follow-up was 41 months (range, 6-211 months) with a median of 25 months. Iliac crest bone graft was harvested in 53 (47.3%) patients through the midline incision used for lumbar fusion. In 59 patients (52.7%), recombinant human bone morphogenetic protein-2 was used with no graft harvest. There was no statistically significant difference in the proportion of patients complaining of tenderness over both or either iliac crest between the two groups. Only 10 patients had pain over the same crest from which the graft was harvested. No correlations between number of levels fused, levels fused, BMI, length of follow-up, and the incidence and severity of bone graft site pain were seen.
The results of this study highlight the difficulty in differentiating pain originating from the graft site versus residual low back pain. The incidence of pain over the iliac crest was similar in patients in which iliac crest was harvested and those in which no graft was harvested.
关于髂嵴骨移植物(ICBG)采集部位持续性疼痛的发生率存在相当大的争议。不同的研究设计导致了各种报道的发生率。
本研究旨在确定髂嵴采集后骨移植物部位疼痛的发生率和严重程度。
横断面。
112 名患者,在三级脊柱中心进行常规术后就诊,接受后路腰椎融合术。
下背部、右侧和左侧髂后嵴疼痛的数字评分量表(0-10)。
一位独立的调查员,不直接参与患者的护理,也不知道融合中使用的骨移植物类型,检查了手术部位以及左右髂后嵴的压痛。检查后,从病历中收集关于移植物材料来源、采集过程中的并发症以及移植物部位缺陷的回填的数据。然后将患者分为是否采集 ICBG。使用卡方检验确定在骨移植物组和无骨移植物组之间,髂嵴疼痛的比例是否存在差异。还确定了体重指数(BMI)、手术时间与骨移植物部位疼痛的发生率和严重程度之间的相关性。
72 名女性和 40 名男性,平均年龄为 56.6 岁(范围,16-84 岁)。平均随访时间为 41 个月(范围,6-211 个月),中位数为 25 个月。53 名(47.3%)患者通过用于腰椎融合的中线切口采集髂嵴骨。在 59 名患者(52.7%)中,使用了重组人骨形态发生蛋白-2,没有采集移植物。两组患者在抱怨双侧或单侧髂嵴压痛的比例方面无统计学差异。只有 10 名患者在取自移植物的同一嵴上有疼痛。未发现融合节段数量、融合节段数量、BMI、随访时间长度与骨移植物部位疼痛的发生率和严重程度之间存在相关性。
本研究结果强调了区分源自移植物部位的疼痛与残余下腰痛的困难。在采集髂嵴骨的患者和未采集移植物的患者中,髂嵴疼痛的发生率相似。