Department of Neurology, Maastricht University Medical Centre, Maastricht, The Netherlands.
Stroke. 2010 Nov;41(11):2687-9. doi: 10.1161/STROKEAHA.110.592725. Epub 2010 Oct 14.
Oxidized low-density lipoprotein (oxLDL) induces endothelial dysfunction and antibody formation. Because endothelial dysfunction is involved in cerebral small vessel disease (CSVD) (dilated Virchow Robin spaces, lacunar infarcts, and white matter lesions), oxLDL antibodies could play a role in CSVD pathogenesis. Therefore, we studied oxLDL antibodies in patients with high prevalence of CSVD: lacunar stroke patients and essential hypertensive patients.
A total of 158 lacunar stroke patients, 158 hypertensive patients, and 43 healthy controls were included. We determined levels of IgG and IgM against hypochlorite (HOCl) and malondialdehyde (MDA) oxLDL using ELISA (values in optical density).
Patients with CSVD had higher levels of IgG-HOCl-oxLDL (0.77 versus 0.70; P<0.01), as well as lower levels of IgM-MDA-oxLDL (0.55 versus 0.65; P<0.05) than patients without such lesions. Higher IgG-HOCl-oxLDL levels were only independently associated with higher numbers of Virchow Robin spaces at the level of the basal ganglia (β=0.218; P<0.001).
An autoinflammatory process with lower levels of IgM antibodies and higher levels of IgG antibodies against oxLDL may be involved in CSVD.
氧化型低密度脂蛋白（oxLDL）可导致血管内皮功能障碍和抗体形成。由于血管内皮功能障碍与脑小血管病（CSVD）（扩大的 Virchow Robin 空间、腔隙性梗死和白质病变）有关，oxLDL 抗体可能在 CSVD 的发病机制中发挥作用。因此，我们研究了 CSVD 高发患者（腔隙性卒中患者和原发性高血压患者）中的 oxLDL 抗体。
共纳入 158 例腔隙性卒中患者、158 例高血压患者和 43 例健康对照者。我们使用 ELISA 测定针对次氯酸（HOCl）和丙二醛（MDA）oxLDL 的 IgG 和 IgM 水平（以吸光度值表示）。
CSVD 患者的 IgG-HOCl-oxLDL 水平（0.77 比 0.70；P<0.01）较高，而 IgM-MDA-oxLDL 水平（0.55 比 0.65；P<0.05）较低。较高的 IgG-HOCl-oxLDL 水平仅与基底节水平的更多 Virchow Robin 空间独立相关（β=0.218；P<0.001）。
针对 oxLDL 的较低水平 IgM 抗体和较高水平 IgG 抗体的自身炎症过程可能与 CSVD 有关。
