Health Center, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
J Atheroscler Thromb. 2010 Dec 26;17(12):1201-11. doi: 10.5551/jat.6106. Epub 2010 Oct 8.
In 1996, adiponectin was reported to be the most abundant transcript in adipose tissue. Animal studies revealed that administering adiponectin improves insulin resistance and blood glucose levels and inhibits atherosclerosis. In the present article, we review the significance of measuring serum high-molecular-weight (HMW) adiponectin levels in human subjects. Our cross-sectional studies revealed that the serum HMW adiponectin concentration was 1.9 times higher in healthy Japanese females than males and had a strong positive correlation with HDL-cholesterol but a negative correlation with BMI and the homeostasis model assessment insulin resistance index (HOMA-IR). They also indicated that the serum HMW adiponectin concentration had a stronger association with HOMA-IR and metabolic syndrome than the total adiponectin concentration. Our longitudinal study, a 6-year follow-up of Japanese men, suggested that a decreased level of HMW adiponectin is a predictor of progression to metabolic syndrome. In another intervention study, lifestyle modification for 3 months induced a decrease in BMI and waist circumference and an increase in serum HMW adiponectin but not the total adiponectin level in 16 Japanese males with metabolic syndrome. Administering thiazolidinediones to diabetic patients increased the serum HMW adiponectin concentration 3 fold and improved glucose and lipid profiles and blood pressure. Some people may inherit a lower serum concentration of adiponectin, and have a higher risk of developing cardiovascular diseases.It is suggested that HMW adiponectin is a useful marker for the evaluation and care of subjects with metabolic syndrome and related disorders.
1996 年，脂联素被报道为脂肪组织中最丰富的转录本。动物研究表明，给予脂联素可以改善胰岛素抵抗和血糖水平，并抑制动脉粥样硬化。在本文中，我们回顾了测量人体血清高分子量（HMW）脂联素水平的意义。我们的横断面研究表明，健康的日本女性血清 HMW 脂联素浓度比男性高 1.9 倍，与 HDL-胆固醇呈强正相关，与 BMI 和稳态模型评估胰岛素抵抗指数（HOMA-IR）呈负相关。它们还表明，血清 HMW 脂联素浓度与 HOMA-IR 和代谢综合征的相关性比总脂联素浓度更强。我们的纵向研究，对日本男性进行了 6 年的随访，表明 HMW 脂联素水平降低是代谢综合征进展的预测指标。在另一项干预研究中，生活方式改变 3 个月导致 16 名患有代谢综合征的日本男性 BMI 和腰围降低，血清 HMW 脂联素增加，但总脂联素水平不变。给予噻唑烷二酮类药物可使糖尿病患者的血清 HMW 脂联素浓度增加 3 倍，并改善血糖和血脂谱以及血压。有些人可能继承了较低的血清脂联素浓度，患心血管疾病的风险更高。建议 HMW 脂联素是评估和护理代谢综合征及相关疾病患者的有用标志物。
