Horio Takuya, Tsujimoto Hironori, Akase Takayoshi, Sakamoto Naoko, Yaguchi Yoshihisa, Hiraki Shuuichi, Aiko Satoshi, Takechi Hanako, Hase Kazuo, Maehara Tadaaki
Department of Surgery, National Defense Medical College.
Gan To Kagaku Ryoho. 2010 Oct;37(10):1945-8.
A case of hyponatremia following the first course of systemic adjuvant chemotherapy with cisplatin (CDDP) and 5-FU in a previously treated patient with esophageal cancer is reported. A 61-year-old man was admitted to our hospital for adjuvant chemotherapy after transthoracic esophagectomy and 3-field lymphadenectomy for esophageal cancer. Six days following chemotherapy, his serum sodium concentration was found to be 118 mEq/L, without edema or dehydration. This hyponatremic state was diagnosed as the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) induced by CDDP, based on the hypo-osmolality of his serum and urine, and an inappropriate level of plasma vasopressin.
报告了1例既往接受过治疗的食管癌患者在接受顺铂（CDDP）和5-氟尿嘧啶的首个疗程全身辅助化疗后出现低钠血症的病例。一名61岁男性因食管癌行胸段食管切除术和三野淋巴结清扫术后入住我院进行辅助化疗。化疗后6天，发现其血清钠浓度为118 mEq/L，无水肿或脱水。根据其血清和尿液的低渗状态以及血浆血管加压素水平异常，该低钠血症状态被诊断为CDDP诱导的抗利尿激素分泌不当综合征（SIADH）。
