Fukabori T, Nakamura T, Kida T, Fujita Y, Goto T, Hiramori N, Fujii T, Iwasaki Y, Nakagawa M
Second Dep. of Medicine, Kyoto Prefectural University of Medicine.
Gan To Kagaku Ryoho. 1991 Jun;18(7):1213-6.
We report a patient with squamous cell carcinoma of bronchus who developed the syndrome of inappropriate antidiuretic hormone secretion (SIADH) after receiving cisplatinum (CDDP) and vindesine (VDS). The 75-year-old man developed right chest pain and was found to have a squamous cell carcinoma of bronchus (stage IIIA, T3N1M0). He was treated by CDDP and VDS. The serum sodium concentration decreased from 136 mEq/l to 120 mEq/l after drug administration. SIADH was diagnosed on the basis of hyponatremia with corresponding serum hypoosmolality and an inappropriately high urinary osmolality due to continued sodium excretion. In our case, SI-ADH was probably induced by CDDP or VDS. Fluid restriction and sodium supplement resulted in a progressive rise in the serum sodium level to 134 mEq/l in 4 days.
我们报告一例支气管鳞状细胞癌患者，其在接受顺铂（CDDP）和长春地辛（VDS）治疗后发生了抗利尿激素分泌不当综合征（SIADH）。这名75岁男性出现右胸痛，被发现患有支气管鳞状细胞癌（ⅢA期，T3N1M0）。他接受了CDDP和VDS治疗。用药后血清钠浓度从136 mEq/L降至120 mEq/L。基于低钠血症伴相应的血清低渗以及因持续排钠导致尿渗透压异常升高，诊断为SIADH。在我们的病例中，SIADH可能是由CDDP或VDS诱发的。限液和补充钠使血清钠水平在4天内逐渐升至134 mEq/L。
