Department of Ophthalmology, School of Medicine, Fukushima Medical University, Fukushima, Japan.
Retina. 2011 Mar;31(3):510-7. doi: 10.1097/IAE.0b013e3181eef053.
To evaluate the subfoveal choroidal thickness in Vogt-Koyanagi-Harada (VKH) disease using enhanced depth imaging optical coherence tomography.
Retrospective observational study. Subfoveal choroidal thickness was measured using enhanced depth imaging optical coherence tomography, in which the optical coherence tomography instrument was placed close enough to the eye to obtain an inverted image, which was averaged for 100 scans. All patients were diagnosed as having the ocular findings of VKH disease with or without extraocular disorders. The patients were followed during their initial treatment with corticosteroids.
All 8 patients (16 eyes) with acute phase VKH disease presented with thickening of the choroid. The serous retinal detachment disappeared in 1 month after corticosteroid treatment. The mean choroidal thickness in 16 eyes decreased from 805 ± 173 μm at the first visit to 524 ± 151 μm at 3 days (P < 0.001) and 341 ± 70 μm by 2 weeks (P < 0.001).
Patients with active VKH disease have markedly thickened choroids, possibly related not only to inflammatory infiltration but also to increased exudation. Both the choroidal thickness and the exudative retinal detachment decreased quickly with corticosteroid treatment. Enhanced depth imaging optical coherence tomography can be used to evaluate the choroidal involvement in VKH disease in the acute stages and may prove useful in the diagnosis and management of this disease noninvasively.
应用增强深度成像光学相干断层扫描评估 Vogt-小柳-原田（VKH）病的中心凹下脉络膜厚度。
回顾性观察性研究。应用增强深度成像光学相干断层扫描测量中心凹下脉络膜厚度，该仪器与眼睛放置得足够近以获得倒置图像，对 100 次扫描进行平均。所有患者均被诊断为具有 VKH 疾病的眼部表现，伴有或不伴有眼外疾病。对所有患者进行了初始皮质类固醇治疗的随访。
8 例（16 只眼）急性 VKH 病患者的脉络膜均增厚。眼外疾病患者的脉络膜厚度也明显增加。皮质类固醇治疗 1 个月后，浆液性视网膜脱离消失。16 只眼中，平均脉络膜厚度从首次就诊时的 805±173μm 降至第 3 天的 524±151μm（P＜0.001）和第 2 周的 341±70μm（P＜0.001）。
活动期 VKH 病患者的脉络膜明显增厚，这可能不仅与炎症浸润有关，还与渗出增加有关。脉络膜厚度和渗出性视网膜脱离均随皮质类固醇治疗迅速减少。增强深度成像光学相干断层扫描可用于评估 VKH 病急性阶段的脉络膜受累情况，并且可能在该疾病的诊断和管理中具有非侵入性的优势。
