Müller Manfred J, Bosy-Westphal Anja, Heller Martin
Institut für Humanernährung und Lebensmittelkunde, Agrar- und Ernährungswissenschaftliche Fakultät, Christian-Albrechts-Universität, Düsternbrooker Weg 17-19, D-24105 Kiel, Germany.
F1000 Biol Rep. 2009 Oct 14;1:75. doi: 10.3410/B1-75.
Recent body composition analyses, together with assessments of insulin resistance, aerobic fitness, and intima-media thickness of the common carotid artery, have shown that metabolically-benign obese subjects have a similar BMI, waist circumference, and subcutaneous abdominal fat compared with non-metabolically-benign obese subjects. Research has suggested that 25-30% of the obese population do not need either treatment or prevention of secondary disorders. Therefore, assessment of functional body composition should replace nutritional status-based risk assessments (such as the body mass index) in both metabolic research and clinical decision making. The concept of 'functional' body composition gives us a more sophisticated view on nutritional status, metabolism, endocrinology, and diseases. Knowledge of detailed body composition enables characterization of biomedical traits which will give functional evidence relating genetic variants.
最近的身体成分分析，连同对胰岛素抵抗、有氧适能以及颈总动脉内膜中层厚度的评估表明，代谢良性肥胖受试者与非代谢良性肥胖受试者相比，具有相似的体重指数、腰围和腹部皮下脂肪。研究表明，25%至30%的肥胖人群既不需要治疗也不需要预防继发性疾病。因此，在代谢研究和临床决策中，功能性身体成分评估应取代基于营养状况的风险评估（如体重指数）。“功能性”身体成分的概念使我们对营养状况、代谢、内分泌学和疾病有了更深入的认识。详细的身体成分知识能够对生物医学特征进行表征，从而为基因变异提供功能证据。
