Al-Shorman Alaa, Al-Domi Hayder, Al-Atoum Muatasem
1 Department of Nutrition and Food Science, School of Agriculture, The University of Jordan, Amman, Jordan.
2 Department of Radiology, Royal Medical Services, Amman, Jordan.
Vascular. 2018 Jun;26(3):285-290. doi: 10.1177/1708538117735457. Epub 2017 Sep 29.
Background Increased carotid intima-media thickness is one of the predictors of future cardiovascular diseases. However, it is still unknown which body composition parameter or anthropometric measure is the best predictor for carotid intima-media thickness change among children and young adolescents. Objective To investigate the associations of body composition and anthropometric measures with carotid intima-media thickness among a group of obese and normal bodyweight schoolchildren. Methods A total of 125 schoolchildren (10-15 years) were recruited from four public schools in Amman, Jordan. Of them, 60 (29 boys and 31 girls) were normal bodyweight students and 65 (35 boys and 30 girls) were obese students. Anthropometric measures, fat mass and fat-free mass were determined. Carotid intima-media thickness of the common artery was measured using high-resolution B-mode ultrasound. Results Compared to normal bodyweight students, obese participants exhibited greater carotid intima-media thickness (mm) (0.45 ± 0.10 vs. 0.38 ± 0.08, p = 0.002) and fat-free mass (kg) (48.01 ± 11.39 vs. 32.65 ±7.65, p < 0.001). Pearson's correlation coefficient and linear regression analysis revealed significant associations ( p≤0.05) between mean carotid intima-media thickness and body mass index, waist circumference, hip circumference, waist-to-hip ratio, fat mass and fat-free mass. Stepwise linear regression analysis revealed that waist circumference was the only measure that was statistically significant ( p ≤ 0.05) with mean carotid intima-media thickness (r = 0.129, p = 0.002). Conclusions Obesity is related to greater carotid intima-media thickness and other cardiovascular risk factors among schoolchildren. Waist circumference is more sensitive in predicting increased carotid intima-media thickness than other body composition or anthropometric measures. Waist circumference measurement in the analysis of future studies assessing the cardiovascular risk among obese children is warranted.
背景 颈动脉内膜中层厚度增加是未来心血管疾病的预测指标之一。然而，对于儿童和青少年而言，哪种身体成分参数或人体测量指标是颈动脉内膜中层厚度变化的最佳预测指标仍不清楚。目的 探讨一组肥胖和正常体重学童的身体成分及人体测量指标与颈动脉内膜中层厚度之间的关联。方法 从约旦安曼的四所公立学校招募了125名学童（10 - 15岁）。其中，60名（29名男孩和31名女孩）为正常体重学生，65名（35名男孩和30名女孩）为肥胖学生。测定了人体测量指标、脂肪量和去脂体重。使用高分辨率B型超声测量颈总动脉的颈动脉内膜中层厚度。结果 与正常体重学生相比，肥胖参与者的颈动脉内膜中层厚度（mm）更大（0.45±0.10 vs. 0.38±0.08，p = 0.002），去脂体重（kg）也更大（48.01±11.39 vs. 32.65±7.65，p < 0.001）。Pearson相关系数和线性回归分析显示，平均颈动脉内膜中层厚度与体重指数、腰围、臀围、腰臀比、脂肪量和去脂体重之间存在显著关联（p≤0.05）。逐步线性回归分析显示，腰围是与平均颈动脉内膜中层厚度具有统计学意义（p≤0.05）的唯一指标（r = 0.129，p = 0.002）。结论 在学童中，肥胖与更大的颈动脉内膜中层厚度及其他心血管危险因素相关。腰围在预测颈动脉内膜中层厚度增加方面比其他身体成分或人体测量指标更敏感。在评估肥胖儿童心血管风险的未来研究分析中，有必要测量腰围。
