Pinner Sophie E, Sahai Erik
Cancer Research UK London Research Institute 44 Lincoln's Inn Fields, London WC2A 3PX UK.
F1000 Biol Rep. 2009 Sep 8;1:67. doi: 10.3410/B1-67.
Cell motility requires the temporal and spatial coordination of the actin cytoskeleton with cell-matrix adhesions. Since their discovery more than 20 years ago, integrins have been at the center of cell-matrix adhesion research. Integrin-mediated adhesions link the actin network to the extracellular matrix and are commonly observed as cells migrate across rigid two-dimensional substrates. However, as more cell motility studies are being conducted in three-dimensional (3D) culture systems and in vivo, the role of integrins has become less clear. Recent work has shown that leukocyte migration in 3D contexts can be integrin-independent and that alternative mechanisms of cell adhesion are employed.
细胞运动需要肌动蛋白细胞骨架与细胞-基质黏附在时间和空间上的协调。自20多年前被发现以来，整合素一直是细胞-基质黏附研究的核心。整合素介导的黏附将肌动蛋白网络与细胞外基质连接起来，并且在细胞迁移穿过刚性二维基质时普遍可见。然而，随着越来越多的细胞运动研究在三维（3D）培养系统和体内进行，整合素的作用变得不那么清晰了。最近的研究表明，白细胞在三维环境中的迁移可以不依赖整合素，并且采用了其他细胞黏附机制。
