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ABCB1转运蛋白基因与抗抑郁反应。

The ABCB1 transporter gene and antidepressant response.

作者信息

Peters Eric J, Reus Victor, Hamilton Steven P

机构信息

Illumina Inc, 9865 Towne Centre Drive, San Diego, CA 92121-1975, USA.

出版信息

F1000 Biol Rep. 2009 Mar 24;1:23. doi: 10.3410/B1-23.

DOI:10.3410/B1-23
PMID:20948663
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2920683/
Abstract

P-glycoprotein, encoded by the ABCB1 gene, may modulate the brain concentration of several antidepressants. Functional genetic variation is thought to exist in this gene, and here we review several studies that have attempted to associate this variation with clinical response to antidepressant treatment.

摘要

由ABCB1基因编码的P-糖蛋白可能会调节几种抗抑郁药在大脑中的浓度。人们认为该基因存在功能性遗传变异，在此我们综述了几项试图将这种变异与抗抑郁治疗的临床反应联系起来的研究。

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The ABCB1 transporter gene and antidepressant response.ABCB1转运蛋白基因与抗抑郁反应。
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2
ABCB1 genotyping in the treatment of depression.ABCB1基因分型在抑郁症治疗中的应用
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Post-mortem analysis of suicide victims shows ABCB1 haplotype 1236T-2677T-3435T as a candidate predisposing factor behind adverse drug reactions in females.对自杀受害者的尸检分析表明，ABCB1单倍型1236T - 2677T - 3435T是女性药物不良反应背后的一个潜在易感因素。
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本文引用的文献

1
Pharmacokinetic genes do not influence response or tolerance to citalopram in the STAR*D sample.在STAR*D研究样本中，药代动力学基因不影响对西酞普兰的反应或耐受性。
PLoS One. 2008 Apr 2;3(4):e1872. doi: 10.1371/journal.pone.0001872.
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An overview of the genetic dissection of complex traits.复杂性状的遗传剖析概述。
Adv Genet. 2008;60:3-34. doi: 10.1016/S0065-2660(07)00401-4.
3
Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression.药物转运蛋白基因ABCB1的多态性可预测抑郁症的抗抑郁治疗反应。
Neuron. 2008 Jan 24;57(2):203-9. doi: 10.1016/j.neuron.2007.11.017.
4
ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder.ABCB1（多药耐药基因1）基因多态性与重度抑郁症患者对帕罗西汀的临床反应相关。
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):398-404. doi: 10.1016/j.pnpbp.2007.09.003. Epub 2007 Sep 15.
5
Dose-dependent effects of the 3435 C>T genotype of ABCB1 gene on the steady-state plasma concentration of fluvoxamine in psychiatric patients.
Ther Drug Monit. 2007 Apr;29(2):185-9. doi: 10.1097/FTD.0b013e318038d835.
6
ABCB1 genotype and PGP expression, function and therapeutic drug response: a critical review and recommendations for future research.ABCB1基因分型与P-糖蛋白的表达、功能及治疗药物反应：一项批判性综述及对未来研究的建议
Pharmacogenomics J. 2007 Jun;7(3):154-79. doi: 10.1038/sj.tpj.6500413. Epub 2006 Sep 12.
7
ABCB1 (P-glycoprotein/MDR1) gene G2677T/a sequence variation (polymorphism): lack of association with side effects and therapeutic response in depressed inpatients treated with amitriptyline.ABCB1（P-糖蛋白/多药耐药蛋白1）基因G2677T/a序列变异（多态性）：与接受阿米替林治疗的抑郁症住院患者的副作用及治疗反应无关
Clin Chem. 2006 May;52(5):893-5. doi: 10.1373/clinchem.2006.066605.
8
Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice.在STAR*D研究中采用基于测量的护理评估西酞普兰治疗抑郁症的疗效：对临床实践的启示
Am J Psychiatry. 2006 Jan;163(1):28-40. doi: 10.1176/appi.ajp.163.1.28.
9
Blood-brain barrier penetration and pharmacokinetics of amitriptyline and its metabolites in p-glycoprotein (abcb1ab) knock-out mice and controls.阿米替林及其代谢产物在P-糖蛋白（abcb1ab）基因敲除小鼠和对照小鼠中的血脑屏障穿透及药代动力学
J Psychiatr Res. 2007 Jan-Feb;41(1-2):179-88. doi: 10.1016/j.jpsychires.2005.10.005. Epub 2006 Jan 4.
10
Amitriptyline or not, that is the question: pharmacogenetic testing of CYP2D6 and CYP2C19 identifies patients with low or high risk for side effects in amitriptyline therapy.用不用阿米替林，这是个问题：对CYP2D6和CYP2C19进行药物遗传学检测可识别出在阿米替林治疗中出现副作用风险低或高的患者。
Clin Chem. 2005 Feb;51(2):376-85. doi: 10.1373/clinchem.2004.041327. Epub 2004 Dec 8.