Sandovici Ionel, Sapienza Carmen
F1000 Biol Rep. 2010 May 24;2:37. doi: 10.3410/B2-37.
Meiotic recombination events typically cluster within narrow regions of the genome termed hotspots. A series of recent papers reveals that PRDM9, a C2H2-type zinc-finger protein with histone H3 lysine 4 methyltransferase activity, plays a major role in the specification of hotspots. The zinc fingers that contact DNA in a sequence-dependent manner evolve rapidly and are under positive selection, leading to differences in the location of recombination hotspots as well as hybrid sterility.
减数分裂重组事件通常聚集在基因组中被称为热点的狭窄区域内。最近的一系列论文表明，PRDM9是一种具有组蛋白H3赖氨酸4甲基转移酶活性的C2H2型锌指蛋白，在热点的指定中起主要作用。以序列依赖性方式与DNA接触的锌指快速进化并处于正选择之下，导致重组热点位置以及杂种不育的差异。
