John Drake Marcus
Bristol Urological Institute Southmead Hospital, Bristol, BS10 5NB UK.
F1000 Med Rep. 2010 Jan 27;2:6. doi: 10.3410/M2-6.
Botulinum neurotoxin has achieved substantial clinical benefits in neurogenic detrusor overactivity. More contentious has been its extension to management of refractory idiopathic detrusor overactivity, in which risk of impaired voiding function and consequent need for intermittent catheterisation may counteract the quality-of-life benefits of improved storage function. Several issues remain uncertain for this unlicensed treatment, and clear insights into long-term consequences are needed before it can be regarded as an established mainstream treatment.
肉毒杆菌神经毒素在神经源性逼尿肌过度活动症中已取得显著的临床疗效。然而，将其应用于难治性特发性逼尿肌过度活动症的治疗则更具争议性，因为在这种情况下，排尿功能受损的风险以及随之而来的间歇性导尿需求可能会抵消改善储尿功能给生活质量带来的益处。对于这种未经许可的治疗方法，仍有几个问题尚不确定，在其被视为一种成熟的主流治疗方法之前，需要对其长期后果有清晰的认识。
