Cantu Giulio, Riccio Stefano, Colombo Sarah, Pompilio Madia, Formillo Paolo
National Cancer Institute of Milan Via Venezian, 1, 20133 Milano Italy.
F1000 Med Rep. 2010 Mar 15;2:17. doi: 10.3410/M2-17.
Human papillomavirus (HPV) is detected in a subset of patients with head and neck squamous cell carcinoma, most frequently in tumors in the Waldeyer's ring (palatine tonsil and base of tongue). Several studies suggest that patients with HPV-positive tumors have better survival with either concurrent chemoradiation therapy or surgery followed by radiation compared with HPV-negative patients. However, some possible confounding clinicopathologic variables may challenge the validity of this statement, for example, some authors used the TNM (tumor, node, metastasis) grouping stage while others used the primary tumor (T stage), and other studies have demonstrated that tumors with advanced T stage were less likely to be infected with HPV. A large clinical trial with stratification of patients according to all known tumor prognostic factors is crucial to solve the question.
在一部分头颈鳞状细胞癌患者中检测到了人乳头瘤病毒（HPV），最常见于瓦尔代尔环（腭扁桃体和舌根）的肿瘤中。多项研究表明，与HPV阴性患者相比，HPV阳性肿瘤患者接受同步放化疗或手术加放疗后的生存率更高。然而，一些可能存在混淆的临床病理变量可能会对这一说法的有效性提出挑战，例如，一些作者使用TNM（肿瘤、淋巴结、转移）分期分组，而另一些作者使用原发肿瘤（T分期），并且其他研究表明，T分期较晚的肿瘤感染HPV的可能性较小。根据所有已知肿瘤预后因素对患者进行分层的大型临床试验对于解决这个问题至关重要。
