Arbyn Marc, Andersson Kristin, Bergeron Christine, Bogers John-Paul, von Knebel-Doebertitz Magnus, Dillner Joakim
Unit of Cancer Epidemiology, Scientific Institute of Public Health, Brussels, Belgium.
Methods Mol Biol. 2011;675:279-98. doi: 10.1007/978-1-59745-423-0_15.
A cervical cytology biobank (CCB) is an extension of current cytopathology laboratory practice consisting in the systematic storage of Pap smears or liquid-based cytology samples from women participating in cervical cancer screening with the explicit purpose of facilitating future scientific research and quality audit of preventive services. A CCB should use an internationally agreed uniform cytology terminology, be integrated in a national or regional screening registry, and linked to other registries (histology, cancer, and vaccination). Legal and ethical principles concerning personal integrity and data safety must be respected strictly. Biobank-based studies require approval from ethical review boards. A CCB constitutes a nearly inexhaustible resource to perform fundamental and applied biologic research. In particular, it can contribute in answering questions on the natural history of HPV infection and HPV-induced lesions and cancers, screening effectiveness, exploration of new biomarkers, and surveillance of short- and long-term effects of the introduction of HPV vaccination. To understand the limitations of CCB, more studies are needed on quality of samples in relation to sample type, storage procedures, and duration of storage.
宫颈细胞学生物样本库（CCB）是当前细胞病理学实验室实践的延伸，包括系统存储参与宫颈癌筛查的女性的巴氏涂片或液基细胞学样本，其明确目的是促进未来的科学研究以及对预防服务的质量审核。CCB应使用国际公认的统一细胞学术语，纳入国家或地区筛查登记系统，并与其他登记系统（组织学、癌症和疫苗接种）相链接。必须严格遵守有关个人诚信和数据安全的法律及伦理原则。基于生物样本库的研究需要获得伦理审查委员会的批准。CCB构成了进行基础和应用生物学研究的几乎取之不尽的资源。特别是，它有助于回答有关HPV感染及HPV诱导的病变和癌症的自然史、筛查效果、新生物标志物的探索以及HPV疫苗接种引入后的短期和长期影响监测等问题。为了解CCB的局限性，需要针对样本质量与样本类型、存储程序及存储时长的关系开展更多研究。
