IGFBP5 启动子中的功能性多态性（-1195T>C）与头颈部癌症风险的关联。
Association between a functional polymorphism (-1195T>C) in the IGFBP5 promoter and head and neck cancer risk.
机构信息
Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
出版信息
Head Neck. 2011 May;33(5):650-60. doi: 10.1002/hed.21514. Epub 2010 Oct 14.
Abstract
BACKGROUND
To the best of our knowledge, no studies to date have evaluated roles of insulin-like growth factor binding protein 5 (IGFBP5) polymorphisms in risk of squamous cell carcinoma of the head and neck (SCCHN).
METHODS
A hospital-based study of 1082 patients with SCCHN and 1120 cancer-free controls was performed to investigate associations between 2 functional polymorphisms, -1195T>C and -709G>C, in the IGFBP5 promoter region and SCCHN risk.
RESULTS
We demonstrated that the transcription factor, activator protein 1 (AP-1), differentially bound to T or C variants at -1195 in the promoter to regulate the IGFBP5 promoter activity and that the C variant genotypes were associated with deferential risk of late-stage SCCHN, compared to the TT genotype, particularly for human papillomavirus (HPV)-unrelated sites (adjusted odds ratio [OR], 2.21; 95% confidence interval [CI], 1.19-4.11 for CC vs TT).
CONCLUSION
The IGFBP5 -1195T>C polymorphism is functional and may potentially be a biomarker for susceptibility to late-stage SCCHN.
摘要
背景
据我们所知，目前尚无研究评估胰岛素样生长因子结合蛋白 5（IGFBP5）多态性在头颈部鳞状细胞癌（SCCHN）风险中的作用。
方法
对 1082 例 SCCHN 患者和 1120 例无癌对照进行了基于医院的研究，以调查 IGFBP5 启动子区域中-1195T>C 和-709G>C 这两个功能多态性与 SCCHN 风险之间的关联。
结果
我们证明，转录因子激活蛋白 1（AP-1）在启动子处-1195 处与 T 或 C 变体不同地结合，以调节 IGFBP5 启动子活性，并且 C 变体基因型与晚期 SCCHN 的风险降低有关，与 TT 基因型相比，尤其是与人类乳头瘤病毒（HPV）无关的部位（调整后的优势比[OR]，2.21；95%置信区间[CI]，1.19-4.11，CC 与 TT）。
结论
IGFBP5-1195T>C 多态性是功能性的，可能是晚期 SCCHN 易感性的生物标志物。
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