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[庆大霉素的微生物学研究]

[Microbiological study of gentamiycin].

作者信息

Chaĭkovskaia S M, Vakulenko N A, Braginskaia P S, Makarova R A

出版信息

Antibiotiki. 1975 Oct;20(10):903-7.

PMID:2095
Abstract

Gentamycin prepared at the All-Union Research Institute of Antibiotics did not differ by its antibacterial spectrum and the activity level from gentamycin samples from other countries. By its activity against clinical strains of Ps. aeruginosa gentamycin was somewhat inferior than polymyxin but much more superior than carbenicillin. An agar-diffusion method using Bac. pumilus NTCC 8241 as the test microbe was developed for determination of gentamycin activity. The gentamycin sulfate complex and the components of gentamycin had the same activity levels, antibacterial spectrum and diffusion capacity.

摘要

全苏抗生素研究所制备的庆大霉素,其抗菌谱和活性水平与其他国家的庆大霉素样品并无差异。就其对铜绿假单胞菌临床菌株的活性而言,庆大霉素略逊于多粘菌素,但远优于羧苄青霉素。开发了一种以短小芽孢杆菌NTCC 8241作为测试微生物的琼脂扩散法来测定庆大霉素的活性。硫酸庆大霉素复合物和庆大霉素的各组分具有相同的活性水平、抗菌谱和扩散能力。

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