Department of Cellular and Molecular Physiology, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, PA 17033, USA.
Biochem J. 2011 Jan 1;433(1):139-44. doi: 10.1042/BJ20101228.
dcAdoMet (decarboxylated S-adenosylmethionine) is an essential intermediate in the synthesis of polyamines. Its content is normally very low, amounting to less than 5% of that of S-adenosylmethionine itself. It was found that in mice lacking spermine synthase there was a large increase in dcAdoMet and that overexpression of spermine synthase reduced the amount of this nucleoside. There was also an increase in dcAdoMet in cells derived from patients with Snyder-Robinson syndrome, a rare X-linked recessive human disease caused by SMS gene mutations that greatly reduce the content of spermine synthase. These results suggest that there is an inverse relationship between the amount of spermine synthase protein and the content of dcAdoMet and raise the possibility that some of the abnormalities seen in mammals deficient in spermine synthase might be due to changes in dcAdoMet pools.
dcAdoMet（脱羧基 S-腺苷甲硫氨酸）是多胺合成中的一个必需中间产物。其含量通常非常低，不到 S-腺苷甲硫氨酸本身的 5%。研究发现，在缺乏精脒合酶的小鼠中，dcAdoMet 大量增加，而过表达精脒合酶则减少了这种核苷的含量。在 Snyder-Robinson 综合征患者的细胞中也发现了 dcAdoMet 的增加，这是一种罕见的 X 连锁隐性遗传性疾病，由 SMS 基因突变引起，极大地降低了精脒合酶的含量。这些结果表明，精脒合酶蛋白的含量与 dcAdoMet 的含量之间存在反比关系，并提出了这样一种可能性，即缺乏精脒合酶的哺乳动物中出现的一些异常可能是由于 dcAdoMet 池的变化所致。
