视网膜母细胞瘤蛋白的免疫病理学研究。

Sawaguchi S, Peng Y, Wong F, Tso M O

Department of Ophthalmology, Lions of Illinois Eye Research Institute, University of Illinois, Chicago.

Trans Am Ophthalmol Soc. 1990;88:51-61; discussion 61-2.

We investigated the immunoreactivity of the retinoblastoma protein in eight retinoblastoma tumors of different stages of differentiation. All undifferentiated tumor cells failed to show immunoreactivity. In one patient, who had a family history of retinoblastoma and had been treated by radiation, the tumor had a large area of undifferentiated cells and small independent retinocytomas. The tumor cells in the retinocytoma and the cone cells in the adjacent retina, but not the undifferentiated tumor cells, showed positive staining with two anti-Rb antibodies. The immunoreactivity may be related to radiation or differentiation of retinoblastoma and cone cells.

我们研究了视网膜母细胞瘤蛋白在八个不同分化阶段的视网膜母细胞瘤肿瘤中的免疫反应性。所有未分化的肿瘤细胞均未显示免疫反应性。在一名有视网膜母细胞瘤家族史且接受过放射治疗的患者中，肿瘤有大片未分化细胞和小的独立视网膜细胞瘤。视网膜细胞瘤中的肿瘤细胞以及相邻视网膜中的视锥细胞显示出两种抗Rb抗体的阳性染色，但未分化的肿瘤细胞则未显示。这种免疫反应性可能与视网膜母细胞瘤和视锥细胞的放射或分化有关。