Mukai N, Kalter S S, Cummins L B, Matthews V A, Nishida T, Nakajima T
Science. 1980 Nov 28;210(4473):1023-5. doi: 10.1126/science.7434012.
Three of 21 newborn baboons injected intraocularly with human adenovirus type 12 developed an intravitreal mass 12 to 36 months later. Two of the masses were indistinguishable from human retinoblastoma, a retinal tumor that afflicts children. To our knowledge this is the first time a retinoblastoma-like tumor has been induced experimentally by adenovirus type 12 in a nonhuman primate.
