健康志愿者静脉注射和口服二甲茚定后的药代动力学
Pharmacokinetics of dimetindene after intravenous and oral administration to healthy volunteers.
作者信息
Arnera V, Wermeille M, Wellman M, Llull J B, Althaus M A, Balant L P
机构信息
Clinical Pharmacology, Zyma S.A., Nyon, Switzerland.
出版信息
Arzneimittelforschung. 1990 Dec;40(12):1346-8.
PMID:2095130
Abstract
The pharmacokinetics of dimetindene (dimethindene maleate, Fenistil, CAS 3614-69-5) were studied after its intravenous and oral administration to 8 healthy male volunteers. Serum concentrations were measured for 48 h using an enzyme-linked immunosorbent assay. Pharmacokinetic parameters (AUC, t1/2, CLs, Vd and F) were calculated using the clearance approach.
摘要
对8名健康男性志愿者静脉注射和口服二甲茚定（马来酸氯苯那敏，Fenistil，CAS 3614-69-5）后，研究了其药代动力学。使用酶联免疫吸附测定法测量48小时的血清浓度。采用清除率法计算药代动力学参数（AUC、t1/2、CLs、Vd和F）。
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