（6-去氧-糖基-6-基）砜衍生物的高效合成及其对 Ca2+-ATPase 的影响。
Efficient synthesis of (6-deoxy-glycopyranosid-6-yl) sulfone derivatives and their effect on Ca2+-ATPase.
机构信息
Division of Molecular Medicine, Bose Institute, A.J.C. Bose Centenery Campus, P-1/12, C. I. T. Scheme VII-M, Kolkata 700054, India.
出版信息
Eur J Med Chem. 2010 Dec;45(12):6012-9. doi: 10.1016/j.ejmech.2010.09.069. Epub 2010 Oct 7.
PMID:20952103
Abstract
Synthesis of a series of novel (6-deoxy-glycopyranosid-6-yl) sulfone derivatives has been achieved using a general synthetic strategy. Yields were excellent in every case. The synthetic compounds were evaluated for their biological potential against Ca2+-ATPase, an important enzyme involves in transporting Ca2+ across the cell membranes.
摘要
已经使用一般的合成策略合成了一系列新型（6-脱氧-吡喃糖苷-6-基）砜衍生物。在每种情况下，产率都非常优异。评估了这些合成化合物对 Ca2+-ATPase 的生物潜力，Ca2+-ATPase 是一种参与将 Ca2+ 穿过细胞膜运输的重要酶。
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