Animal Disease Diagnosis Center, National Veterinary Research and Quarantine Service, Anyangsi, Gyeonggido, Korea.
Poult Sci. 2010 Nov;89(11):2426-31. doi: 10.3382/ps.2010-00911.
In South Korea, 32 sequences of chicken infectious anemia virus (CIAV) from various flocks of breeder and commercial chickens were genetically characterized for the first time. Phylogenetic analysis of the viral protein 1 gene, including a hypervariable region of the CIAV genome, indicated that Korean CIAV strains were separated into groups II, IIIa, and IIIb. Strains were commonly identified in great-grandparent and grandparent breeder farms as well as commercial chicken farms. In the field, CIAV strains from breeder farms had no clinical effects, but commercial farm strains were associated with depression, growth retardation, and anemia regardless of the group from which the strain originated. In addition, we identified 7 CIAV genomes that were similar to vaccine strains from vaccinated and unvaccinated breeder flocks. These data suggest that further studies on pathogenicity and vaccine efficacy against the different CIAV group are needed, along with continuous CIAV surveillance and genetic analysis at breeder farms.
在韩国，首次对来自不同种鸡群的 32 个鸡传染性贫血病毒（CIAV）序列进行了遗传特征分析。对包括 CIAV 基因组高变区在内的病毒蛋白 1 基因的系统发育分析表明，韩国 CIAV 株分为 II 组、IIIa 组和 IIIb 组。在曾祖代和祖代种鸡场以及商品鸡场中，常见到各种毒株。在田间，种鸡场的 CIAV 株没有临床症状，但商业农场的毒株与抑郁、生长迟缓、贫血有关，而与株起源的组别无关。此外，我们还鉴定出 7 株 CIAV 基因组与来自接种和未接种疫苗的种鸡群的疫苗株相似。这些数据表明，需要进一步研究不同 CIAV 组的致病性和疫苗效力，并在种鸡场进行持续的 CIAV 监测和遗传分析。
