巴西黑人人群中的巴氏血红蛋白

Hemoglobin Bart's in a Brazilian black population.

作者信息

Sonati M F, Costa F F

机构信息

Departamento de Patologia Clínica, Faculdade de Medicina, Universidade Estadual de Campinas, Brasil.

出版信息

Braz J Med Biol Res. 1990;23(5):395-6.

PMID:2095287

Abstract

Hemoglobin Bart's was measured spectrophotometrically after electrophoresis on cellulose acetate strips in cord blood from 320 full-term randomly selected black newborns from the University Hospital of Campinas, State of São Paulo, in the southeast of Brazil. Hb Bart's was detected in 38 of the 320 newborns (11.9%), with the levels presenting the following bimodal distribution: 10.3% of the infants in the 1-3.5% range and 1.6% in the 5-10% range. The data suggest that the frequency of alpha-thalassemia gene in the Brazilian black population is 0.125 since individuals with Bart's Hb in the 5-10% range are usually alpha(+)-thalassemia homozygotes.

摘要

在巴西东南部圣保罗州坎皮纳斯大学医院，对320名随机选取的足月黑人新生儿的脐血进行醋酸纤维素薄膜电泳后，用分光光度法测定了血红蛋白Bart's。在320名新生儿中有38名检测到血红蛋白Bart's（11.9%），其水平呈现以下双峰分布：1 - 3.5%范围内的婴儿占10.3%，5 - 10%范围内的占1.6%。数据表明，巴西黑人人群中α地中海贫血基因的频率为0.125，因为血红蛋白Bart's在5 - 10%范围内的个体通常是α（+）-地中海贫血纯合子。