Khatri M L, Shafi M, Benghazil M, Machina A, Sassi E
Department of Dermatology, Central Hospital and Faculty of Medicine, Al-Fatch University of Medical Sciences, Tripoli, Libya, .
Indian J Dermatol Venereol Leprol. 1995 Mar-Apr;61(2):96-8.
We have treated 4 cases of pyoderma gangrenosum in infancy and childhood in past 2 years. The ages at onset were 6 months, 8 months, 6 months and 11.5 years respectively. Initial lesions were papulopustular in 3 and nodular in 1 patients but later on all of them developed ulcerative lesions with erythematous, violaceous, infiltrated or undermined edges. The lesions were numerous in 3 patients but few in 1 patient. The first patient had very high leucocyte count. In the second patient skin lesions of PG followed measles vaccinations. We could not reveal any association in the other two patients. None of the patient responded to antibiotic therapy. Three patients were treated successfully with dapsone and one with a combination of dapsone and prednisolone. We conclude that pyoderma gangrenosum is not so rare in infancy and it is more likely to occur without associated systemic diseases.
在过去两年中，我们治疗了4例婴幼儿及儿童坏疽性脓皮病。发病年龄分别为6个月、8个月、6个月和11.5岁。3例患者初始皮损为丘疹脓疱型，1例为结节型，但随后所有患者均发展为溃疡性皮损，边缘呈红斑状、紫蓝色、浸润性或潜行性。3例患者皮损较多，1例患者皮损较少。第1例患者白细胞计数非常高。第2例患者坏疽性脓皮病的皮肤损害发生在麻疹疫苗接种后。我们在另外两名患者中未发现任何关联。所有患者对抗生素治疗均无反应。3例患者使用氨苯砜治疗成功，1例患者使用氨苯砜和泼尼松龙联合治疗成功。我们得出结论，坏疽性脓皮病在婴儿期并不罕见，且更有可能在无相关系统性疾病的情况下发生。
