Department of Microbiology and Immunology, Charles Darby Children's Research Institute, Hollings Cancer Center, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA.
J Oncol. 2010;2010. doi: 10.1155/2010/516047. Epub 2010 Oct 5.
B-cell lymphomas arise at distinct stages of cellular development and maturation, potentially influencing antigen (Ag) presentation and T-cell recognition. Burkitt lymphoma (BL) is a highly malignant B-cell tumor associated with Epstein-Barr Virus (EBV) infection. Although BL can be effectively treated in adults and children, leading to high survival rates, its ability to mask itself from the immune system makes BL an intriguing disease to study. In this paper, we will provide an overview of BL and its association with EBV and the c-myc oncogene. The contributions of EBV and c-myc to B-cell transformation, proliferation, or attenuation of cellular network and immune recognition or evasion will be summarized. We will also discuss the various pathways by which BL escapes immune detection by inhibiting both HLA class I- and II-mediated Ag presentation to T cells. Finally, we will provide an overview of recent developments suggesting the existence of BL-associated inhibitory molecules that may block HLA class II-mediated Ag presentation to CD4+ T cells, facilitating immune escape of BL.
B 细胞淋巴瘤发生在细胞发育和成熟的不同阶段，可能影响抗原（Ag）呈递和 T 细胞识别。伯基特淋巴瘤（BL）是一种与 Epstein-Barr 病毒（EBV）感染相关的高度恶性 B 细胞肿瘤。尽管 BL 在成人和儿童中的治疗效果显著，生存率较高，但 BL 能够逃避免疫系统的能力使其成为一个有趣的研究疾病。本文将概述 BL 及其与 EBV 和 c-myc 癌基因的关联。总结 EBV 和 c-myc 对 B 细胞转化、增殖或细胞网络和免疫识别或逃逸的衰减的贡献。我们还将讨论 BL 通过抑制 HLA Ⅰ类和Ⅱ类介导的 T 细胞 Ag 呈递来逃避免疫检测的各种途径。最后，我们将概述最近的研究进展，这些进展表明存在与 BL 相关的抑制分子，这些分子可能阻止 HLA Ⅱ类介导的 CD4+ T 细胞 Ag 呈递，从而促进 BL 的免疫逃逸。
