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Clinical implications of slow sulphoxidation of thioridazine in a poor metabolizer of the debrisoquine type.

作者信息

Meyer J W, Woggon B, Baumann P, Meyer U A

出版信息

Eur J Clin Pharmacol. 1990;39(6):613-4. doi: 10.1007/BF00316110.

DOI:10.1007/BF00316110
PMID:2095351
Abstract
摘要

相似文献

1
Clinical implications of slow sulphoxidation of thioridazine in a poor metabolizer of the debrisoquine type.在异喹胍型弱代谢者中硫利达嗪慢硫氧化的临床意义。
Eur J Clin Pharmacol. 1990;39(6):613-4. doi: 10.1007/BF00316110.
2
Plasma levels of thioridazine and metabolites are influenced by the debrisoquin hydroxylation phenotype.
Clin Pharmacol Ther. 1991 Mar;49(3):234-40. doi: 10.1038/clpt.1991.22.
3
Debrisoquine oxidation phenotype during neuroleptic monotherapy.抗精神病药物单一疗法期间的异喹胍氧化表型
Eur J Clin Pharmacol. 1991;41(5):467-70. doi: 10.1007/BF00626371.
4
Debrisoquine oxidation in schizophrenic patients treated with neuroleptics.
Pharmacol Res Commun. 1988 Dec;20(12):1103-4. doi: 10.1016/s0031-6989(88)80747-1.
5
Thioridazine steady-state plasma concentrations are influenced by tobacco smoking and CYP2D6, but not by the CYP2C9 genotype.硫利达嗪的稳态血浆浓度受吸烟和CYP2D6影响，但不受CYP2C9基因型影响。
Eur J Clin Pharmacol. 2003 May;59(1):45-50. doi: 10.1007/s00228-003-0576-4. Epub 2003 Mar 28.
6
Metoprolol alpha-hydroxylation is a poor probe for debrizoquine oxidation (CYP2D6) polymorphism in Jordanians.在约旦人中，美托洛尔α-羟化作用对于地布喹氧化（CYP2D6）多态性而言并非良好的检测指标。
Eur J Clin Pharmacol. 1994;47(4):311-4. doi: 10.1007/BF00191160.
7
Genetic polymorphism of debrisoquine (CYP2D6) and proguanil (CYP2C19) in South Pacific Polynesian populations.南太平洋波利尼西亚人群中异喹胍（CYP2D6）和氯胍（CYP2C19）的基因多态性。
Eur J Clin Pharmacol. 1998 Jul;54(5):431-5. doi: 10.1007/s002280050488.
8
Debrisoquine oxidation in an Italian population: a study in healthy subjects and in schizophrenic patients.
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9
Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations.欧洲人群中异喹胍和甲妥英的羟化多态性
Eur J Clin Pharmacol. 1990;39(6):533-7. doi: 10.1007/BF00316090.
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Isolation of a possible new metabolite of thioridazine and mesoridazine from human plasma.从人血浆中分离出硫利达嗪和美索达嗪一种可能的新代谢物。
Res Commun Chem Pathol Pharmacol. 1974 Mar;7(3):489-96.

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Contributions of ionic interactions and protein dynamics to cytochrome P450 2D6 (CYP2D6) substrate and inhibitor binding.离子相互作用和蛋白质动力学对细胞色素P450 2D6（CYP2D6）底物及抑制剂结合的贡献。
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Pharmacogenetic aspects of drug-induced torsade de pointes: potential tool for improving clinical drug development and prescribing.药物诱导的尖端扭转型室性心动过速的药物遗传学方面：改善临床药物开发和处方的潜在工具。
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Pharmacokinetic factors in the adverse cardiovascular effects of antipsychotic drugs.

本文引用的文献

1
Simultaneous determination of thioridazine and its S-oxidized and N-demethylated metabolites using high-performance liquid-chromatography on radially compressed silica.使用径向压缩硅胶上的高效液相色谱法同时测定硫利达嗪及其S-氧化和N-去甲基代谢物。
J Chromatogr. 1982 Sep 10;231(2):377-91. doi: 10.1016/s0378-4347(00)81862-9.
2
Polymorphic dextromethorphan metabolism: co-segregation of oxidative O-demethylation with debrisoquin hydroxylation.多态性右美沙芬代谢：氧化O-去甲基化与异喹胍羟基化的共分离。
Clin Pharmacol Ther. 1985 Dec;38(6):618-24. doi: 10.1038/clpt.1985.235.
3
GC and GC-MS procedures for simultaneous phenotyping with dextromethorphan and mephenytoin.
抗精神病药物心血管不良反应中的药代动力学因素。
Clin Pharmacokinet. 2004;43(1):33-56. doi: 10.2165/00003088-200443010-00003.
4
Contribution of human cytochrome p-450 isoforms to the metabolism of the simplest phenothiazine neuroleptic promazine.人细胞色素P-450同工型对最简单的吩噻嗪类抗精神病药物丙嗪代谢的贡献。
Br J Pharmacol. 2003 Apr;138(8):1465-74. doi: 10.1038/sj.bjp.0705195.
5
Cytochrome p450 phenotyping/genotyping in patients receiving antipsychotics: useful aid to prescribing?接受抗精神病药物治疗患者的细胞色素P450表型/基因型分析：对处方开具是否有帮助？
Clin Pharmacokinet. 2002;41(7):453-70. doi: 10.2165/00003088-200241070-00001.
6
Pharmacokinetics and metabolism of thioridazine during co-administration of tricyclic antidepressants.三环类抗抑郁药与硫利达嗪合用时的药代动力学及代谢情况。
Br J Pharmacol. 2000 Sep;131(2):287-95. doi: 10.1038/sj.bjp.0703540.
7
Metabolism, pharmacogenetics, and metabolic drug-drug interactions of antipsychotic drugs.抗精神病药物的代谢、药物遗传学及代谢性药物相互作用
Cell Mol Neurobiol. 1999 Aug;19(4):491-510. doi: 10.1023/a:1006938908284.
8
Cytochrome P450 enzymes and drug metabolism--basic concepts and methods of assessment.细胞色素P450酶与药物代谢——评估的基本概念和方法
Cell Mol Neurobiol. 1999 Jun;19(3):309-23. doi: 10.1023/a:1006993631057.
9
Genetically determined adverse drug reactions involving metabolism.涉及代谢的基因决定的药物不良反应。
Drug Saf. 1993 Jul;9(1):60-77. doi: 10.2165/00002018-199309010-00006.
10
Pharmacokinetics of chlorpromazine and key metabolites.氯丙嗪及其关键代谢物的药代动力学。
Eur J Clin Pharmacol. 1993;45(6):563-9. doi: 10.1007/BF00315316.
用于右美沙芬和美芬妥因同时表型分析的气相色谱和气相色谱 - 质谱联用程序。
Clin Chim Acta. 1988 Feb 15;171(2-3):211-22. doi: 10.1016/0009-8981(88)90146-5.
4
Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.异喹胍代谢缺陷人类常见遗传缺陷的特征分析。
Nature. 1988 Feb 4;331(6155):442-6. doi: 10.1038/331442a0.
5
Two mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs.人类细胞色素P-450db1基因（P450C2D1）的两个突变等位基因，与地布卡因及其他药物的遗传代谢缺陷相关。
Proc Natl Acad Sci U S A. 1988 Jul;85(14):5240-3. doi: 10.1073/pnas.85.14.5240.
6
The molecular mechanisms of two common polymorphisms of drug oxidation--evidence for functional changes in cytochrome P-450 isozymes catalysing bufuralol and mephenytoin oxidation.药物氧化两种常见多态性的分子机制——催化布呋洛尔和美芬妥因氧化的细胞色素P-450同工酶功能改变的证据
Xenobiotica. 1986 May;16(5):449-64. doi: 10.3109/00498258609050251.
7
Defective N-oxidation of sparteine in man: a new pharmacogenetic defect.人司巴丁N-氧化缺陷：一种新的药物遗传学缺陷。
Eur J Clin Pharmacol. 1979 Sep;16(3):183-7. doi: 10.1007/BF00562059.
8
Polymorphic hydroxylation of Debrisoquine in man.人对异喹胍的多态性羟基化作用。
Lancet. 1977 Sep 17;2(8038):584-6. doi: 10.1016/s0140-6736(77)91430-1.