al-Hadidi H F, Irshaid Y M, Rawashdeh N M
Department of Pharmacology, Faculty of Medicine, Jordan University of Science and Technology, Irbid.
Eur J Clin Pharmacol. 1994;47(4):311-4. doi: 10.1007/BF00191160.
The frequency distribution of the 8-h urinary ratio of log metoprolol/alpha-hydroxymetoprolol was assessed in 65 healthy, unrelated Jordanian volunteers. There was no apparent bimodality in the frequency distribution of this ratio among the subjects studied. The frequency of the poor metabolizer phenotype of metoprolol alpha-hydroxylation was 1.5% (one subject). There was a significant correlation (r = 0.61, P < 0.05, n = 39) between the log metoprolol/alpha-hydroxymetoprolol and the log debrisoquine/4-hydroxydebrisoquine ratios. However, the frequency of poor metabolizer status of debrisoquine among the 39 subjects was 7.7% (three subjects). Only one of the poor metabolizer of metoprolol alpha-hydroxylation. These findings indicate that metoprolol alpha-hydroxylation by CYP2D6 represents a poor probe for studying debrisoquine polymorphism in Jordanians.
在65名健康、无亲缘关系的约旦志愿者中评估了美托洛尔/α-羟基美托洛尔8小时尿排泄率的频率分布。在所研究的受试者中，该比率的频率分布没有明显的双峰现象。美托洛尔α-羟化代谢不良者表型的频率为1.5%（1名受试者）。美托洛尔/α-羟基美托洛尔对数与异喹胍/4-羟基异喹胍对数比率之间存在显著相关性（r = 0.61，P < 0.05，n = 39）。然而，在这39名受试者中，异喹胍代谢不良者状态的频率为7.7%（3名受试者）。美托洛尔α-羟化代谢不良者中只有1人。这些发现表明，CYP2D6介导的美托洛尔α-羟化对于研究约旦人群中的异喹胍多态性而言并非理想的探针。
