Department of Neurological Science, Second University of Naples, Piazza Miraglia 2, 80131, Naples, Italy.
Neurol Sci. 2011 Feb;32(1):117-23. doi: 10.1007/s10072-010-0433-z. Epub 2010 Oct 16.
Brain derived neurotrophic factor (BDNF) regulates several CNS physiological and pathological processes. To investigate in multiple sclerosis (MS) patients, the relationship between the Val66Met polymorphism of BDNF and clinical markers of disease activity and MRI markers of focal and diffuse brain pathologies. 45 MS patients and 34 healthy controls (HCs) were genotyped and subjected to clinical-MRI examination. Global white matter fraction (gWM-f), gray matter-f (GM-f), cerebrospinal fluid-f (CSF-f), and abnormal WM-f were measured. We studied 26 Val/Val and 19 Val/Met patients and 23 Val/Val and 11 Val/Met HCs. We found that Val/Val patients had lower GM-f and higher CSF-f than Val/Val HCs; such differences were not statistically significant comparing Val/Met patients to HCs. The regression analysis showed that both Val/Met genotype and relapse number were associated with lower CSF-f. Our data suggest that Met allele might be a protective factor against MS as it is associated to a lower brain atrophy.
脑源性神经营养因子（BDNF）调节着中枢神经系统的多种生理和病理过程。为了研究多发性硬化症（MS）患者，BDNF 的 Val66Met 多态性与疾病活动的临床标志物和局灶性及弥漫性脑病理的 MRI 标志物之间的关系。对 45 名 MS 患者和 34 名健康对照者（HCs）进行基因分型和临床 MRI 检查。测量全脑白质分数（gWM-f）、灰质分数（GM-f）、脑脊液分数（CSF-f）和异常 WM-f。我们研究了 26 名 Val/Val 和 19 名 Val/Met 患者和 23 名 Val/Val 和 11 名 Val/Met HCs。我们发现 Val/Val 患者的 GM-f 低于 Val/Val HCs，CSF-f 高于 Val/Val HCs；但 Val/Met 患者与 HCs 之间的这些差异无统计学意义。回归分析表明，Val/Met 基因型和复发次数均与较低的 CSF-f 相关。我们的数据表明，Met 等位基因可能是 MS 的保护因素，因为它与较低的脑萎缩有关。
