Department of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria, Santander, Spain.
Prog Neuropsychopharmacol Biol Psychiatry. 2013 Aug 1;45:201-6. doi: 10.1016/j.pnpbp.2013.05.014. Epub 2013 Jun 6.
Functional gene polymorphisms modulating neuroplasticity might mediate brain longitudinal structural changes in schizophrenia. The present study aimed to explore possible effects of BDNF Val66Met polymorphism variations on progressive structural brain changes after 3 years from the first episode of psychosis.
Patients were part of a large epidemiological and longitudinal intervention program of first-episode psychosis, carried out at the University Hospital Marqués de Valdecilla, Cantabria, Spain. Eighty first-episode patients and 54 healthy controls were included in the final analyses. Brain magnetic resonance imaging (baseline and 3-year follow-up) and BDNF genotype, and clinical and functional outcome were investigated.
We did not detect significant association between brain changes and BDNF Val66Met polymorphism variations in patients and controls (all p>0.060). At baseline, there were no significant associations between brain anomalies and BDNF genotype. Functional deficits were similar in Met-carrier and Val homozygote patients after 3-year follow-up (X(2) = 0.66; p = 0.564); there was no relationship between significant volume change across time and functional outcome. Otherwise, Met-carrier controls had significant high rates of alcohol-consumption (p = 0.019) compared to Val homozygote controls.
Our findings do not support the notion that BDNF genotype variations may mediate brain macroscopic morphological changes across time.
调节神经可塑性的功能性基因多态性可能介导精神分裂症的大脑纵向结构变化。本研究旨在探讨 BDNF Val66Met 多态性变化对首发精神病后 3 年的大脑进行性结构变化的可能影响。
患者是西班牙坎塔布里亚大学医院马尔克斯·德·瓦尔德西利亚进行的大型首发精神病的流行病学和纵向干预计划的一部分。最终分析包括 80 名首发精神病患者和 54 名健康对照者。进行了脑磁共振成像（基线和 3 年随访）和 BDNF 基因型以及临床和功能结局的研究。
我们未发现患者和对照组中脑变化与 BDNF Val66Met 多态性变化之间存在显著关联（所有 p 值均>0.060）。在基线时，脑异常与 BDNF 基因型之间无显著关联。在 3 年随访后，Met 携带者和 Val 纯合子患者的功能缺陷相似（X²=0.66；p=0.564）；没有发现时间上的显著体积变化与功能结局之间存在关系。另外，Met 携带者对照组的饮酒量明显较高（p=0.019），而 Val 纯合子对照组则无此情况。
我们的发现不支持 BDNF 基因型变异可能介导大脑宏观形态随时间变化的观点。
