Vit V V
Oftalmol Zh. 1990(8):484-9.
A study of the character of changes in melanoma cells "in vitro" subjected to successive beta-radiation and light energy of low intensity has revealed a more expressed loss of cells as compared with a "pure" ionizing action. Essential differences in the cells density in the monolayer appear already by the 3d-8th day and reach the maximum 2-3 weeks later. The dynamics of changes in the cells density isn't connected with the cellular type of the tumor and initial density isn't connected with the cellular type of the tumor and initial density of their distribution in the monolayer. The duration of the culture existence becomes shorter. If monolayers not subjected to the action perished after 54.0 +/- 6.2 days, after beta-radiation 35.2 +/- 2.4 days later, then after combined action they perished 17.2 +/- 2.6 days later. Thus, the effect was revealed that is actually opposite to a recently discovered phenomenon of photoreactivation of ionizing injury. Despite difficulty of interpreting possible mechanisms of the discovered phenomenon, it is already possible to suggest about its possibility to be used in treatment of pigmentary new formations.
一项关于黑色素瘤细胞在体外接受连续β辐射和低强度光能后变化特征的研究表明，与“单纯”电离作用相比，细胞损失更为明显。单层细胞密度的显著差异在第3至8天就已出现，并在2至3周后达到最大值。细胞密度变化的动态过程与肿瘤的细胞类型无关，初始密度也与肿瘤的细胞类型及其在单层中的初始分布密度无关。培养物存活的持续时间缩短。未受该作用的单层细胞在54.0±6.2天后死亡，经β辐射后在35.2±2.4天后死亡，而经联合作用后在17.2±2.6天后死亡。因此，发现了一种实际上与最近发现的电离损伤光复活现象相反的效应。尽管难以解释该发现现象的可能机制，但已经可以推测其在色素性新生物治疗中的应用可能性。
