Departments of Neurology and Epidemiology, Columbia University, New York, New York, USA.
Ann N Y Acad Sci. 2010 Oct;1207:97-106. doi: 10.1111/j.1749-6632.2010.05736.x.
Innate inflammation plays an important role in the pathogenesis and progression of atherosclerosis, plaque rupture, thrombosis, and stroke. Inflammatory biomarkers related to innate inflammation, including acute phase proteins, may predict first stroke. The utility of high-sensitivity C-reactive protein and other related markers may diminish among populations with established vascular risk. Other biomarkers, including lipoprotein-associated phospholipase A2, may provide complementary information about prognosis after stroke or subclinical vascular disease. The innate immune system originally evolved to provide protection against bacterial infections. Moreover, infections may also contribute to stroke risk. Summary measures representing multiple chronic infections have been associated with risk of stroke and atherosclerosis. Acute infections, particularly respiratory infections, have also been found to serve as precipitants of stroke in recent epidemiological studies. These findings could have clinical implications. Further studies are needed to determine the role of innate inflammation and infection in stroke pathogenesis and prevention.
先天炎症在动脉粥样硬化、斑块破裂、血栓形成和中风的发病机制和进展中起着重要作用。与先天炎症相关的炎症生物标志物，包括急性期蛋白，可能可以预测首次中风。在已经存在血管风险的人群中，高敏 C 反应蛋白和其他相关标志物的效用可能会降低。其他生物标志物，包括脂蛋白相关磷脂酶 A2，可能会提供关于中风或亚临床血管疾病预后的补充信息。先天免疫系统最初是为了提供对细菌感染的保护而进化的。此外，感染也可能导致中风风险增加。代表多种慢性感染的综合指标与中风和动脉粥样硬化的风险有关。在最近的流行病学研究中，急性感染，特别是呼吸道感染，也被发现是中风的诱因。这些发现可能具有临床意义。需要进一步的研究来确定先天炎症和感染在中风发病机制和预防中的作用。
