Honegger J, Buchfelder M, Rupprecht H, Schwarz W
Neurochirurgische Klinik, Universität Erlangen-Nürnberg.
Z Exp Chir Transplant Kunstliche Organe. 1990;23(4):236-40.
The serum-concentrations of the trace-elements zinc and copper were assessed before and after neurosurgical interventions in 60 patients. On the day of surgery the mean values of zinc and copper showed a significant decrease, but had reached their preoperative level one week later. While a influence of dexamethasone on the serum zinc levels could not be deducted, the serum copper concentrations seem to be influenced by dexamethasone. These changes seem to be connected with the activation of the hypothalamus-pituitary-adrenal axis during surgical stress.
对60例患者在神经外科手术干预前后的微量元素锌和铜的血清浓度进行了评估。手术当天，锌和铜的平均值显著下降，但一周后已恢复到术前水平。虽然无法推断地塞米松对血清锌水平有影响，但血清铜浓度似乎受地塞米松影响。这些变化似乎与手术应激期间下丘脑 - 垂体 - 肾上腺轴的激活有关。
