Christrup L L, Bonde J, Rasmussen S N, Rassing M R
Department of Pharmaceutics, Royal Danish School of Pharmacy, Copenhagen, Denmark.
Acta Pharm Nord. 1990;2(6):371-6.
The absorption of verapamil administered orally in chewing gum (23.4-29.7 mg) and perorally in tablets (80 mg) to seven healthy volunteers in a study using an open cross-over design, was compared. Following peroral administration the mean +/- SD AUC/D was (5.4 +/- 1.9) x 10(-3) micrograms ml-1 h per microgram dose and after administration of chewing gum (6.6 +/- 2.3) x 10(-3) micrograms ml-1 h per microgram dose (NS). The AUC ratio of verapamil to the metabolite norverapamil was 1.5 after oral and 0.8 after peroral administration, indicating that a part of the verapamil administered in chewing gum was absorbed through the oral mucosa.
在一项采用开放交叉设计的研究中，比较了7名健康志愿者口服含23.4 - 29.7毫克维拉帕米的口香糖和口服80毫克维拉帕米片剂后的吸收情况。口服给药后，平均±标准差的AUC/D为（5.4±1.9）×10⁻³微克·毫升⁻¹·小时/微克剂量，而服用口香糖后为（6.6±2.3）×10⁻³微克·毫升⁻¹·小时/微克剂量（无显著性差异）。口服维拉帕米与代谢产物去甲维拉帕米的AUC比值在口服给药后为1.5，口服口香糖后为0.8，这表明口香糖中给药的一部分维拉帕米是通过口腔黏膜吸收的。
